多发性骨髓瘤的临床及全身磁共振分析  

The clinic and whole-body analysis of multiple myeoma by MRI

作　　者：刘许慧[1] 袁梅[1] 秦斌[1] 王德杭[1] 

机构地区：[1]南京医科大学第一附属医院放射科,江苏南京210029

出　　处：《医学影像学杂志》2011年第1期98-102,共5页Journal of Medical Imaging

摘　　要：目的:分析多发性骨髓瘤的临床特征及其全身磁共振表现,探讨全身磁共振分期与临床分期之间的关系。方法:采用Siemens 3.0T磁共振对15例经病理证实的多发性骨髓瘤患者进行全身检查。采用Fisher精确概率法对磁共振及临床两种分期方法进行分析。结果:多发性骨髓瘤最常见的临床表现有骨痛、贫血、乏力、肝脾肿大和浅表淋巴结肿大等;15例患者中全身磁共振表现为正常型4例,弥漫型3例,局灶型3例,混合型4例,胡椒面型1例。磁共振分期为Ⅰ期4例,Ⅱ期3例,Ⅲ期8例,临床分期为Ⅰ期1例,Ⅱ期4例,Ⅲ期10例。两种分期方法进行统计学分析得出P=0.46>0.05。结论:多发性骨髓瘤临床表现多样化,主要表现为骨痛;全身磁共振成像对于多发性骨髓瘤具有较好的成像效果和评估价值;两种分期方法之间没有统计学差异。Objective：To analyze the clinical manifestations of multiple myeloma and the images of whole-body magnetic resonance,to explore the relationship between MRI stage and clinical stage.Methods：15 multiple myeloma patients enrolled.Histological proof of multiple myeloma was obtained in all cases.Fisher exact test is used to analyze MRI stage and clinical stage.Results：The most common clinical manifestations of multiple myeloma are bone pain,fatigue,anemia,and hepatosplenomegaly and superficial lymphadenopathy.15 cases were classified as normal type（4 cases）,diffuse type（3 cases）,focal type（3 cases）,mixed type（4 cases） and ＂salt and pepper＂ type（1 case）.Conclusion：Multiple myeloma＇s clinical manifestations is divergent,the most common is bone pain.Whole-body MR has good image effects and evaluation value for multiple myeloma.And,there is no statistical significant difference between MRI stage and clinical stage.

关 键 词：多发性骨髓瘤 全身磁共振成像 

分 类 号：R738.1[医药卫生—肿瘤] R445.2[医药卫生—临床医学]