人类神经Tau蛋白结构与功能研究进展  

Synopsis of research of human neuronal Tau protein

作　　者：陈永辉[1] 

机构地区：[1]中国科学院生物物理研究所,北京100101

出　　处：《生命科学》1999年第4期184-185,171,共3页Chinese Bulletin of Life Sciences

摘　　要：Tau属微管结合蛋白，对神经细胞的生长发育、物质运输及信息传导起着重要作用。该分子不具有明显的二级结构；其生物学功能的调节主要是通过磷酸化和去磷酸化来实现。目前的研究表明，早老性痴呆等疾病与Tau分子高级结构的异常改变和功能丧失有关。Tau is a member of microtubule-associated proteins.It plays an important rolein neuronal development as well as transportation of substance and signal in nerve system.Thesecondary structure of this molecule is not distinguishably observed.Regulation of Tau's functionis mainly dependent upon phosphorylation and dephosphorylation.Some recent reports indicatethat Alzheimer's diseajse and some other nervous diseases are correlated to disorder of the structureand function of Tau.

关 键 词：人类神经Tau蛋白 早老性痴呆 结构与功能 

分 类 号：Q513[生物学—生物化学] R749.1[医药卫生—神经病学与精神病学]