兰索拉唑治疗中老年非糜烂性胃食管反流病临床观察  

A clinical study of lansoprazole treatment the middle-aged and elderly patient with non-erosive reflux disease

作　　者：王晶璠[1] 盖亚男[1] 余晓兵[1] 

机构地区：[1]空军总医院干部病房,北京100142

出　　处：《中华保健医学杂志》2011年第1期54-56,共3页Chinese Journal of Health Care and Medicine

摘　　要：目的探讨兰索拉唑治疗中老年非糜烂性胃食管反流病(NERD)的疗效。方法将经内镜明确诊断的172例老年NERD患者随机分为2组,治疗组88例,口服兰索拉唑30mg,1次/d,莫沙必利5mg,3次/d。对照组84例,口服法莫替丁20mg,2次/d,莫沙必利5mg,3次/d。分别于治疗1周、2周、4周观察症状改善情况及不良反应。结果治疗4周后治疗组和对照组症状改善总有效率分别为95.4%和73.8%,差异有统计学意义(P<0.05)。结论兰索拉唑治疗中老年NERD效果显著。Objective To investigate the effect of lansoprazole in the treatment of non-erosive reflux disease（NERD）in middle-aged and elderly patient.Methods One hundred and seventy-two patients with endoscopically prove non-erosive reflux disease（NERD）were randomly divide into two groups.Treatment group 88 cases received lansoprazole 30mg once daily,while control group 84 cases received famotidine 20mg two time daily and mosapride 5mg three time daily.After 1W,2W,4W improvement in symptoms and adverse effect were record.Results After 4 weeks treatment the total symptom improvement rate in treatment group and control group were 95.4% and 73.8% respectively.There were significant differences in total symptom improvement rates between the two group（P0.05）.Conclusions Lansoprazole is highly effective in the treatment of ono-erosive reflux diseasea than famotidine.

关 键 词：胃食管反流病 非糜烂性胃食管反流病 兰索拉唑 法莫替丁 莫沙必利 

分 类 号：R571[医药卫生—消化系统]