氯丙米嗪合并氯丙嗪治疗强迫症疗效分析  

The effectiveness analysis of obsessive-compulsive disorder (OCD) treated by chlorpromazine and clomipramine

作　　者：雷雨[1] 刘伟[1] 

机构地区：[1]华中科技大学同济医学院附属精神病医院武汉精神卫生中心,湖北武汉430022

出　　处：《中国民康医学》2011年第5期558-559,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨氯丙米嗪合并氯丙嗪治疗强迫症的临床疗效。方法:对原用氯丙米嗪治疗为主的52例强迫症患者随机分成两组,一组加用氯丙嗪(研究组),另一组仍用氯丙米嗪(对照组),治疗8周,用Y-BOCS、HAMA评定两组精神症状变化,用t检验对照分析。结果:研究组的HAMA、Y-BOCS总分比对照组明显下降,且有显著性差异(P<0.01)。结论:强迫症患者,采用氯丙嗪合并氯丙米嗪治疗,可提高疗效。Objective ：To observe the clinical efficacy of chlorpromazine and clomipramine in the treatment of obsessive - compulsive disorder （OCD）. Methods ：52 cases of obsessive -compulsive disorder patients, who were cured by clomipramine in the previous treatment, were divided randomly into two groups. One of them, which was called as the treatment group, were cured combined with chlorpromazine for the next 8 weeks, while the other one （the control group） were still going on treated by clomipramine only during the period. Over the duration of treatment, Y - BOCS and HAMA were used to evaluate the changes of mental symptoms of patients of these two groups. At the same time, t - test was also used to analyse them. Results： The total score of Y - BOCS and HAMA of the treatment group was decreased sharply compared with that of the control group and the differences between these two groups are significant （P 〈 0.01 ）. Conclusions： The curative effect of obsessive - compulsive disorder （OCD） will be improved by using chlorpromazinc combined with clomipramine.

关 键 词：氯丙嗪 强迫症 氯丙米嗪 

分 类 号：R749.79[医药卫生—神经病学与精神病学]