K-ras及hMSH2蛋白在45岁以下妇女子宫内膜癌中的表达  

Expression of K-ras and hMSH2 in Endometrial Carcinoma in Women Under 45 Years Old

作　　者：邓开玉[1] 谷永红[2] 陈芸[3] 

机构地区：[1]怀化医学高等专科学校妇产科教研室,湖南怀化418000 [2]中南大学湘雅三医院病理科,湖南长沙410013 [3]云南省肿瘤医院病理科,云南昆明650000

出　　处：《医学临床研究》2011年第2期293-296,共4页Journal of Clinical Research

摘　　要：[目的]探讨K-ras及hMSH2蛋白在年轻妇女子宫内膜癌（EC）组织中的表达及相关性.[方法]选取因子宫病变行子宫全切的标本66例,其中EC 42例、子宫内膜非典型增生6例、正常子宫内膜18例.测定其内膜组织中K-ras及hMSH2的表达.[结果]①在正常子宫内膜、子宫内膜不典型增生及EC中K-ras均呈高表达,且差异有显著性（P＜0.05） hMSH2的表达率分别为44.44%、33.33%、73.81%,差异有显著性（P＜0.05）.②K-ras及hMSH2在EC中的表达与临床分期、组织学分级、肌层浸润深度及有无淋巴转移无关（P＞0.05）.③在EC中K-ras与hMSH2表达呈正相关（rs=0.351,P＜0.05）.[结论]K-ras表达发生在EC的早期,与预后无关 hMSH2的表达与肿瘤细胞的增殖有关.[Objective] To study the expressions and relationship between K ras and hMSH2 in endometri al carcinoma（EC） in young women under 45 years old. [Methods] Totally 66 uterine specimens which were excised for uterine diseases, including 42 cases of EC, 6 cases of atypical endometrial hyperplasia and 18 cases of normal endometrium, were selected. The expressions of K-ras and hMSH2 in the tissues of endometrium were detected. [Results] The expressions of K-ras were higher in normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma, and there were significant differences among them（ P〈0.05）. The expression rates of hMSH2 were 44. 44% 33.33% and 73.81%,respectively, and there were also significant differences（ P〈0. 005）. But the expressions of K-ras and hMSH2 had no relationship with clinical stages, histological grades, myometrial invasion depth and lymphatic metastasis whether or not（ P〉0.05）. In endometrial carcinoma group, there was positive correlation between K ras and hMSH2 （rs=0. 351, P〈0.05）. [Conclusion] The expression of K-ras occurs in the early stage of endometrial carcinoma and has no relation with prognosis. The expression of hMSH2 is related with the proliferation of tumor cells.

关 键 词：子宫内膜肿瘤/病理学 基因 ras 

分 类 号：R737.33[医药卫生—肿瘤]