黛力新治疗非糜烂性反流病合并焦虑抑郁32例临床观察  

作　　者：郑红[1] 郑容[2] 

机构地区：[1]四川省自贡市沿滩区人民医院内科,643030 [2]四川省自贡市第五人民医院内科,643020

出　　处：《当代医学》2011年第6期136-137,共2页Contemporary Medicine

摘　　要：目的观察运用黛力新治疗非糜烂性反流病(NERD)合并焦虑、抑郁状态患者的疗效。方法运用Hamilton焦虑量表(HAMA)和Hamilton抑郁量表(HAMD)评分筛选出合并焦虑、抑郁状态的NERD患者32例,随机分为A组16例(实验组)和B组16例(对照组),B组采用奥美拉唑20mgpobid+莫沙必利5mgpotid治疗,A组在B组治疗的基础上加用黛力新10.5mgqd(清晨口服),两组疗程均为8周,比较两组患者治疗后症状缓解和生活质量改善情况。结果与治疗前相比,实验组治疗后症状明显缓解,有效率81.3%,生活质量量表评分提高率25.6%,优于对照组的56.3%和8.8%,两项指标差异均有统计学意义(P<0.05)。结论对NERD患者应注意焦虑、抑郁等精神心理障碍的评估,对合并焦虑、抑郁状态患者行常规治疗联合黛力新改善焦虑、抑郁情绪,可以有效缓解躯体症状,提高生活质量。Objective To observe the therapeutic effects of application Deanxit that treatment of non-erosive reflux disease （NERD） combined with anxiety and depression in patients. Methods 32 patients with NERD combined with anxiety and depression, evaluated with Hamilton Rating Scale for Depression （HAMD） and Hamilton Anxiety Scale （HAMA）, were randomly assigned into two groups： group A （treated group） and group B （control group）. 16 cases of group B took Omeprazole 20mg po.bid, Mosapride 5mg po.tid （conventional treatment）. 16 cases of group A in the conventional treatment, while was added deanxit 10.5mg po.qd. The period for the treatment was eight weeks. To compared with differences of symptom scale scores and quality of life scale （QoL） scores after 8 weeks. Results The response rate of treated group was 81.3%, as compared with 56.3% of this in the control group after 8 weeks （P〈0.05）. QoL scores in treated group increased 25.6%, as compared with 8.8% of this in the control group （P〈0.05）. Conclusion In patients with NERD, it is necessary to evaluate the levels of anxiety and depression. Combining the conventional treatment and application of Deanxit, is a remarkable effective method for treating NERD combined with anxiety and depression in patients.

关 键 词：非糜烂性反流病(NERD) 黛力新 抑郁 焦虑 

分 类 号：R571[医药卫生—消化系统] R749.2[医药卫生—内科学]