新疆维吾尔族宫颈癌新辅助化疗前后Ki-67、凋亡指数的表达及意义  

Expressions and significances of KI-67 and apoptosis index before and after neoadjuvant chemotherapy in Uigur women with cervical carcinoma in Xinjiang

作　　者：徐跃勋[1] 王英红[2] 

机构地区：[1]石河子大学医学院 [2]石河子大学医学院第一附属医院妇产科

出　　处：《中国妇幼保健》2011年第7期1077-1080,共4页Maternal and Child Health Care of China

基　　金：石河子大学重大攻关项目〔500002213403〕

摘　　要：目的:探讨维吾尔族(维族)宫颈鳞癌组织细胞增殖和凋亡与新辅助化疗疗效的关系。方法:选取20例维族正常宫颈组织,22例维族宫颈鳞癌患者新辅助化疗前后的宫颈组织,分别应用免疫组化SP法和脱氧核糖核苷酸末端转移酶介导dUTP缺口末端标记法(TUNEL)检测组织中的Ki-67核抗原指数(PI)和凋亡指数(AI)。结果:化疗临床有效率为81.8%;化疗前后宫颈鳞癌组织Ki-67增殖指数表达分别为(66.45±16.31)和(38.41±7.46),差异有统计学意义(t=7.33,P<0.05);凋亡指数分别为(6.95±1.50)和(15.73±2.75),经比较差异有统计学意义(t=-13.195,P<0.05);化疗前后有效组和无效组宫颈鳞癌组织Ki-67变化值分别为(30.78±15.56)和(15.75±17.75),经比较差异无统计学意义(t=1.71,P>0.05);凋亡指数变化值分别为(9.16±3.04)和(6.70±1.16),经比较差异无统计学意义(t=1.57,P>0.05)。结论:新辅助化疗能抑制维族宫颈鳞癌细胞增殖,诱导凋亡;化疗后宫颈鳞癌细胞凋亡指数明显上调者可能与良好预后有关。Objective：To explore the relationship between proliferation,apoptosis of cervical squamous cell carcinoma cells and clinical efficiency of neoadjuvant chemotherapy in Uigur women with cervical carcinoma in Xinjiang. Methods：20 normal cervical tissue samples of Uigur women and 22 cervical tissue samples before and after neoadjuvant chemotherapy of Uigur women with cervical squamous cell carcinoma were selected,immunohistochemical SP method and terminal-deoxynucleotidyl transferase mediated dUTP nick end labeling（TUNEL） were used to detect Ki-67 nuclear antigen and apoptosis index. Results：The clinical effective rate of neoadjuvant chemotherapy was 81.8%;Ki-67 proliferation indexes before and after neoadjuvant chemotherapy were（66.45.21±16.31） and（38.41±7.46）,respectively,there was significant difference（t=7.33,P0.05）;apoptosis indexes before and after neoadjuvant chemotherapy were（6.95±1.50） and（15.73±2.75）,respectively,there was significant difference（t=-13.195,P0.05）.The variance values of Ki-67 in effective group and non-effective group before and after neoadjuvant chemotherapy were（30.78±15.56） and（15.75±17.75）,respectively,there was no significant difference（t=1.71,P0.05）;the variance values of apoptosis index in effective group and non-effective group before and after neoadjuvant chemotherapy were（9.16±3.04） and（6.70±1.16）,respectively,there was no significant difference（t=1.57,P0.05）. Conclusion：Neoadjuvant chemotherapy can inhibit proliferation and induce apoptosis of cervical squamous cell carcinoma cells in Uigur women with cervical carcinoma in Xinjing;up-regulation of apoptosis index after neoadjuvant chemotherapy may be related to good prognosis of the disease.

关 键 词：宫颈癌 维吾尔族 KI-67核抗原 凋亡指数 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]