5-氨基酮戊酸光动力疗法治疗未生育妇女宫颈上皮内瘤样变  

Clinical Study on 5-Aminolevulinic Acid-Photodynamic Therapy on Nulliparous Women with CINⅠ

作　　者：王玲[1] 吴红[1] 姚红霞[1] 朱慧庭[1] 陈琦[1] 徐静[1] 

机构地区：[1]同济大学附属第一妇婴保健院,上海200040

出　　处：《中国临床医学》2011年第1期78-79,共2页Chinese Journal of Clinical Medicine

基　　金：上海市浦东新区社发局项目(编号:PW2009D-8)

摘　　要：目的:研究5-氨基酮戊酸光动力疗法(ALA-PDT)治疗未生育妇女宫颈上皮内瘤样变(CINⅠ)的疗效和安全性。方法:采用ALA-PDT法治疗未生育宫颈CINⅠ患者,通过1年的随访,评价患者CIN的复发率以及人乳头瘤病毒(HPV)感染转阴情况。结果:共纳入62例患者,其中48例(77.42%)术后宫颈1次愈合,1例(1.61%)术后1年复发,诊断为CIN II,后行宫颈环形电切术(LEEP)治愈。62患者均为HPV持续感染病例,其中41例(66.13%)经ALA-PDT治疗后转为阴性。4例患者怀孕。结论:ALA-PDT是1种有效、安全的治疗方法,可消除HPV感染,并且术后不会对子宫颈的机能造成影响。Objective：To investigate the efficacy and safety of 5-aminolevulinic acid-photodynamic therapy（ALA-PDT） on nulliparous women with cervical intraepithelial neoplasmⅠ（CINⅠ）.Methods： This was un-randomized,controlled clinical trial.A total of 62 patients with CINⅠ and persistent infection with human papillomavirus（HPV） were enrolled and were treated by ALA-PDT.All the patients were followed for one year.Therapeutic effect and regative conversion of HPV infection were evaluated.Results： During the follow-up,48 cases（77.42%）were cured after one course treatment.One cases developed into CIN II after one year,and who was treated by using loop electrosurgical excision procedure（LEEP）.There were 41 cases（66.13%） with HPV infection turned to be negative.Four cases were pregnant.Conclusions：ALA-PDT is an effective and minimally invasive treatment for CINⅠ,low risk of serious adverse reactions and complications,which also appears to eradicate HPV infection and does not affect the postoperative function of the cervix.

关 键 词：5-氨基酮戊酸 光动力疗法 宫颈上皮内瘤变 

分 类 号：R730.5[医药卫生—肿瘤]