宫腔镜与子宫内膜癌腹水肿瘤细胞播散相关性的Meta分析  

A Meta-Analysis of the Relationship between Peritoneal Cytology and Diagnostic Hysteroscopy in Endometrial Carcinoma

作　　者：顾广宇[1,2] 侯宗萍[1,2] 钱永红[1,2] 

机构地区：[1]南京医科大学附属苏州医院 [2]苏州市立医院妇产科,江苏苏州215000

出　　处：《中国临床医学》2011年第1期82-84,共3页Chinese Journal of Clinical Medicine

摘　　要：目的：探讨宫腔镜应用于诊断子宫内膜癌患者后,是否会增加腹水或腹腔冲洗液中肿瘤细胞的阳性率。方法：检索1990年1月—2009年12月Pubmed、Medline、Embase、中国生物医学文献数据库上公开发表的有关宫腔镜应用于诊断子宫内膜癌后与患者腹水肿瘤细胞阳性率关系的文献,按照入选标准,共有9篇随机对照临床试验的文献纳入本研究,对其研究内容摘录后应用RevMan4.2软件进行分析。结果：宫腔镜应用于诊断子宫内膜癌患者后,与对照组比较有增加腹水肿瘤细胞阳性率的风险,优势比（OR）为1.79,95%可信区间（95%CI）为（1.25~2.57）。结论：根据现有的随机对照研究资料分析,宫腔镜可增加子宫内膜癌患者腹水肿瘤细胞的阳性率,这可能会增加腹腔内癌细胞播散概率,故宫腔镜推广应用于子宫内膜癌患者的诊断尚需谨慎。Objective：To evaluate whether the diagnostic hysteroscopy will increase the risk of tumor cell dissemination.Methods：The literature about the association of hysteroscopy and peritoneal cytology obtained from endometrial carcinoma were searched for according to inclusion and exclusion criteria from January of 1990 to December of 2009 in electronic databases Pubmed,Medline,Embase and CBMD isc.The data in the nine randomized and controlled studies selected were analyzed by RevMan 4.2 software.Results：In patients with endometrial carcinoma,the performance of diagnostic hysteroscopy will increase the positive incidence of peritoneal cytology（odd ratio 1.79,95% confidential intervals 1.25 to 2.57）.Conclutions：According to the achieved controlled trials＇ data,hysteroscopy used in the diagnosis of endometrial carcinoma may facilitate the tumor cell dissemination.Thus,we should be more circumspect in expanding it.

关 键 词：子宫内膜癌 宫腔镜 腹水细胞学 META分析 

分 类 号：R737.33[医药卫生—肿瘤]