卵巢上皮性癌组织中β-catenin、E-cadherin表达变化及意义  

Expression and significance of β-catenin、 E-cadherin in epithelial ovarian cancer

作　　者：魏德娥[1] 仲文玉[1] 马轶飞[1] 徐健[1] 

机构地区：[1]山东大学附属济南市中心医院,济南250014

出　　处：《山东医药》2011年第6期7-9,共3页Shandong Medical Journal

基　　金：济南市卫生局科技计划项目(2008-03)

摘　　要：目的观察卵巢上皮性癌(卵巢癌)组织中-βcatenin、E-cadherin的表达变化,并探讨其意义。方法采用免疫组化SABC法检测49例上皮性卵巢癌、10例交界性囊腺瘤及16例良性卵巢肿瘤患者肿瘤组织中的β-catenin、E-cadherin。结果卵巢癌组织中-βcatenin、E-cadherin的异常表达率分别为79.59%(39/49)、67.35%(33/49),明显高于良性卵巢肿瘤组织的25%(4/16)、0和交界性卵巢囊腺瘤组织的30.00%(3/10)、20.00%(2/10),P均<0.01。良性卵巢肿瘤与卵巢交界性囊腺瘤组织中β-catenin、E-cadherin的异常表达率相比P均>0.05。β-catenin与卵巢癌病理类型、病理分级和腹腔转移有关(P均<0.05)。E-cadherin与卵巢癌病理类型、临床分期、腹腔转移和术后有无残余瘤有关(P均<0.05)。卵巢癌组织中的β-catenin、E-cadherin的异常表达呈正相关(r=0.525 8,P<0.05)。结论卵巢癌组织中-βcatenin、E-cadherin表达下调。二者在卵巢肿瘤发生、发展过程中起重要作用。Objective To investigate the expression of β-catenin,E-cadherin in epithelial ovarian cancer and to explore their clinical significance.Methods Expressions of β-catenin,E-cadherin was detected with immunohistochemistry assay in 49 specimens of epithelial ovarian cancer,10 borderline epithelial ovarian tumors,16 benign epithelial ovarian tumors.Results The abnormal expression of β-catenin and E-cadherin were significantly higher in the ovarian cancer（79.59% and 67.35%） than in the borderline（30.00% and 20.00%） and benign（25% and 0） ovarian epithelial tumors（P0.01）.By comparing with the abnormal expression of β-catenin and E-cadherin in the borderline and benign ovarian epithelial tumors,P0.05.The expression pattern ofβ-catenin was associated with histological subtypes,differentiation stages and peritoneal metastasis（P0.05）.The expression pattern of E-cadherin was associated with histological subtypes,FIGO stages,peritoneal metastasis,and residual size（P0.05）.The expression of beta-catenin and E-cadherin was positively correlated（r= 0.525 8,p0.05） in specimens of ovarian cancer.Conclusions Down-regulation of β-catenin and E-cadherin in specimens of ovarian cancer.They have important effects on pathogenesis and development of ovarian epithelial tumors.

关 键 词：卵巢肿瘤 卵巢癌 Β-连环素 E-钙黏蛋白 

分 类 号：R737.31[医药卫生—肿瘤]