棉酚及其衍生物抗肿瘤机制的研究进展  

Research Progress in Anti-neoplastic Mechanisms of Gossypol and Derivatives

作　　者：付帅[1] 吴勇[1] 

机构地区：[1]昆明医学院附属口腔医院口腔颌面外科,昆明650031

出　　处：《医学综述》2011年第4期524-526,共3页Medical Recapitulate

基　　金：云南省自然科学基金(2009CD207)

摘　　要：棉酚具有多种药理活性,近年来其抗肿瘤作用越来越受到重视。棉酚的抗肿瘤机制尚未完全明确,通过体外和动物实验及一些初步的临床试验证实,棉酚的抗肿瘤机制有线粒体途径、调控细胞的周期蛋白、抑制Bcl-2蛋白的过度表达。亦有研究表明棉酚可以通过使高甲基化的抑癌基因去甲基化达到抗肿瘤作用。Gossypol exhibits multiple pharmacological activities and its anti-neoplastic mechanism has been extensively studied.The anti-neoplastic mechanism of gossypol remains less understood although some in vitro,animal and preliminary clinical studies have documented these effects.The anti-neoplastic mechanisms include mitochondrial pathway,regulation of cell cycle proteins,and inhibition of overexpression of Bcl-2 protein.It is also reported that gossypol demethylates the hypermethylated suppressor genes to activate the anti-neoplastic effects.

关 键 词：棉酚 抗肿瘤 甲基化 去甲基化 抑癌基因 

分 类 号：R739.8[医药卫生—肿瘤]