药物去势和手术去势联合TURP治疗前列腺癌疗效分析  

Efficacy Analysis of Medical Castration and Surgical Castration with Transurethral Resection of Prostate for the Treatment of Prostate Cancer

作　　者：黄昆[1] 朱明[1] 

机构地区：[1]安徽省立医院泌尿外科,合肥230001

出　　处：《医学综述》2011年第4期618-619,共2页Medical Recapitulate

摘　　要：目的研究前列腺癌患者药物去势与手术去势联合经尿道前列腺电切术后患者前列腺特异性抗原(PSA)水平与国际前列腺症状评分(IPSS)的变化。方法 60例研究对象,其中28例行药物去势,32例行手术去势联合经尿道前列腺电切。对比治疗前后PSA及IPSS变化。结果治疗后3个月,两组患者PSA均有明显下降,但组间差异无统计学意义(P>0.05),IPSS评分手术组较药物组下降明显(P<0.01)。结论前列腺癌合并下尿路梗阻的患者更适合行手术去势联合经尿道前列腺电切及抗雄激素药物治疗。Objective To investigate the variation of prostate specific antigen（PSA）and international prostate symptom score（IPSS）in patients with prostate cancer before and after the treatments with medical castration and surgical castration with transurethral resection of prostate（TURP）.Method Patients（n=60）with prostate cancer were included,28 assigned for medical castration and 32 for surgical castration with TURP.The changes in PSA and IPSS were compared before and after the treatments.Results Three month after the treatments,PSA levels in the two groups decreased significantly,showing no significant intergroup difference（P0.05）.IPSS decreased more significantly in patients undergoing surgical castration than in those undergoing medical castration（P0.01）.Conclusion Surgical castration integrating TURP and androgen antagonist medication was more suitable for prostate cancer patients complicated with lower urinary tract obstruction.

关 键 词：TURP 去势 抗雄激素药物 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]