VEGF-C、VEGFR-3在直肠癌组织中的表达及其相关因素分析  

Expressions and clinical significance of VEGF-C and VEGFR-3 in rectal cancer

作　　者：商嵩山[1] 丁元升[1] 张剑权[2] 符国珍[2] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]海口市人民医院胃肠外科,海南海口570208

出　　处：《临床和实验医学杂志》2011年第5期327-329,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血管内皮生长因子C(VEGF-C)和血管内皮生长因子受体3(VEGFR-3)在直肠癌中的表达及其与临床病理学特征之间的关系。方法运用免疫组织化学(SP法)检测55例直肠癌组织及相应切缘组织中VEGF-C、VEGFR-3蛋白的表达。结果 VEGF-C和VEGFR-3蛋白在直肠癌组织中,表达率分别为63.6%和60.0%,在切缘组织表达率较低,差异有统计学意义(P<0.05),且VEGF-C和VEGFR-3在直肠癌中的表达呈正相关关系(r=0.386,P<0.05),有无淋巴转移及不同Dukes分期的癌组织中VEGF-C和VEGFR-3表达率差异有统计学意义(P<0.05)。结论 VEGF-C和VEGFR-3在直肠癌组织中均呈高表达,并且两者的表达与直肠癌淋巴结转移情况密切相关。Objective To investigate the expressions of vascular endothelial growth factor C（VEGF-C） and vascular endothelial growth factor receptor 3（VEGFR-3） in rectal cancer,and their relationship with the characteristics of clinical pathology.Methods Expressions of VEGF-C and VEGFR-3 were detected in 55 tissue samples of rectal cancer and 55 tissue samples of corresponding normal tissue with immunohistochemistry.Results Significant differences were found in the positive rates of VEGF-C and VEGFR-3 expressions between normal large intestine tissues and tissues of rectal cancer（P〈0.05）.The expression of VEGF-C was positively correlated with the expression of VEGFR-3 in rectal cancer（r=0.386,P〈0.05）.The expressions of VEGF-C and VEGFR-3 were higher in rectal cancer of Dukes stages A and B than in Dukes stages C and D,and higher in rectal cancer without lymph node metastasis than in rectal cancer with lymph node metastasis（P〈0.05）.Conclusion The expressions of VEGF-C and VEGFR-3 were high in rectal cancer,and both of them have significant realation with lymphnode metastasis.

关 键 词：直肠癌 血管内皮生长因子C 血管内皮生长因子受体3 

分 类 号：R735.3[医药卫生—肿瘤]