前列腺癌内分泌治疗现状  

The status of endocrine therapy on prostate cancer

作　　者：杨翌[1] 王毅[1] 秦国庆[1] 李建军[1] 魏建华[1] 钱坤[1] 蒋鸿涛[1] 周浩[1] 

机构地区：[1]南华大学附属第二医院泌尿外科,湖南衡阳421001

出　　处：《现代生物医学进展》2011年第2期371-374,共4页Progress in Modern Biomedicine

摘　　要：前列腺癌(prostatecancerPC)是欧美国家男性发病率最高的恶性肿瘤,近年来其在我国的发病率也逐年升高。雄激素在PC的发生、发展过程中扮演着重要的角色,所以内分泌治疗一直是前列腺癌研究领域的重点,但是其可能诱发激素非依赖型PC这也是临床医学面临的一大问题。本文就前列腺癌内分泌治疗的分类、作用机制、用药策略及临床效果等作一综述。Prostate cancer（PC） is the most common malignancy of male in Europe and American.The incidence increased in recent years in our country.Steroid hormones play an important role in occurrence and development of prostate cancer,so endocrine therapy for prostate cancer has been the focus in this field.It may induce the hormone refractory prostate cancer,which is one of the major difficul-ties of clinical medicine.Classification,mechanism,administration strategy and clinical effects of endocrine therapy on prostate cancer are reviewed in this article.

关 键 词：前列腺癌 激素抵抗 激素依赖 内分泌治疗 

分 类 号：R737.25[医药卫生—肿瘤]