Disseminated intravascular coagulation scores as predictors for progressive hemorrhage and neurological prognosis following traumatic brain injury  

作　　者：Yirui Sun Caihua Xi Ersong Wang Jianqing Wang Yong Liu Hua Liu Qiang Yuan Haijun Yao Liangfu Zhou Jin Hu 

机构地区：[1]Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China [2]Shanghai Sixth Hospital, Shanghai Jiao Tong University, Shanghai 200233, China [3]Department of Neurosurgery, Ruijin Minhang District Central Hospital, Shanghai 201100, China [4]Nanjing Brain Hospital, Nanjing Medical University, Nanjing 100027, Jiangsu Province, China

出　　处：《Neural Regeneration Research》2011年第2期136-142,共7页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,No. 81000518 and 30770824;China Postdoc-toral Science Foundation,No. 201003237;the Scien-tific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China;Shang-hai Pujiang Program,No. 09PJ1408300;the Science and Technology Commission of Shanghai Municipality Project,No. 10JC1402300.

摘　　要：Coagulation abnormalities, such as disseminated intravascular coagulation （DIC）, are associated with progressive hemcrrhagic injury （PHI） following head trauma. However, the exact relationship between coagulopathy and PHI remains unclear. The present study utilized a scoring system defined by the International Society of Thrombosis and Haemostasis to investigate whether a high DIC score is predictive for PHI. This study was a multicenter prospective design involving four hospitals, a 6-month observation, and follow-up. Of 352 traumatic brain injury （TBI） patients, serial CT scan indicated approximately one third of patients developed progressive hemorrhage, which was most frequently observed in the frontal, temporal, and orbitofrontal lobes of patients with brain contusion. PHI-positive patients exhibited poor prognosis, as indicated by prolonged length of hospital/intensive care unit stay and high mortality. More importantly, a DIC score after TBI, as well as patient age and sex, could serve as predictors for PHI. In addition, DIC scores were closely associated with injury severity. Therefore, the DIC scoring system facilitated early PHI diagnosis in TBI patients, and DIC scores might serve as a valuable predictor for TBI patients with PHI.Coagulation abnormalities, such as disseminated intravascular coagulation （DIC）, are associated with progressive hemcrrhagic injury （PHI） following head trauma. However, the exact relationship between coagulopathy and PHI remains unclear. The present study utilized a scoring system defined by the International Society of Thrombosis and Haemostasis to investigate whether a high DIC score is predictive for PHI. This study was a multicenter prospective design involving four hospitals, a 6-month observation, and follow-up. Of 352 traumatic brain injury （TBI） patients, serial CT scan indicated approximately one third of patients developed progressive hemorrhage, which was most frequently observed in the frontal, temporal, and orbitofrontal lobes of patients with brain contusion. PHI-positive patients exhibited poor prognosis, as indicated by prolonged length of hospital/intensive care unit stay and high mortality. More importantly, a DIC score after TBI, as well as patient age and sex, could serve as predictors for PHI. In addition, DIC scores were closely associated with injury severity. Therefore, the DIC scoring system facilitated early PHI diagnosis in TBI patients, and DIC scores might serve as a valuable predictor for TBI patients with PHI.

关 键 词：COAGULOPATHY disseminated intravascular coagulation disseminated intravascular coagulation scoring intracranial hemorrhage progressive hemorrhagic injury traumatic brain injury 

分 类 号：S852.44[农业科学—基础兽医学] F407.7[农业科学—兽医学]