微小RNA与肿瘤相关性研究  

MicroRNA and cancer

作　　者：程文[1] 高建平[1] 张征宇[1] 

机构地区：[1]南京军区南京总医院泌尿外科,南京医学博士210002

出　　处：《医学研究生学报》2011年第2期203-207,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30772278)

摘　　要：微小(microRNA,miRNA)是一种内源性的类似于siRNA的小RNA分子,由高等真核生物基因组编码、非编码蛋白,长度大约为22个核苷酸RNA片段,通过核酸序列的互补性结合到特定的靶mRNA上,并调节、翻译或降解靶mRNA来调控基因表达。近年来,miRNA作为生物体重要的基因调控分子与疾病的关系尤其是与肿瘤的关系备受关注。现就miRNA与肿瘤相关性作一综述。microRNA（miRNA） is an endogenous siRNA-like small RNA molecule from the genome of higher eukaryotes encoding non-coding protein with the length of about 22 nucleotide RNA fragments.It controls gene expression through the nucleic acid sequence combination of complementary to a specific target of the regulation of mRNA translation or degradation of target mRNA.In recent years,miRNA organisms as important elements of gene regulation,and its relationship with diseases and cancer in particular were extremely studied.The present article reviews the miRNAs and cancer.

关 键 词：微小RNA 肿瘤 基因 基因表达 

分 类 号：R730.59[医药卫生—肿瘤]