弥漫性神经胶质瘤病4例分析  

Diffuse Gliomatosis: Report and Analysis of 4 Cases

作　　者：廖焕权[1] 王鸿轩[2] 陈红兵[1] 王莹[1] 贺涓涓[1] 洪华[1] 

机构地区：[1]中山大学附属第一医院神经内科,广东广州510080 [2]中山大学附属第二医院神经内科,广东广州510120

出　　处：《中山大学学报（医学科学版）》2011年第1期136-138,共3页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(30971028);广东省自然科学基金(06021232);广东省科技计划(2007B031502003);广州市科技计划(2009Z1-E021);中山大学附属第一医院人才支持计划(18700112)

摘　　要：【目的】探讨弥漫性神经胶质瘤病的临床表现、影像学及病理学特点。【方法】回顾性总结经病理确诊的4例弥漫性神经胶质瘤病的临床资料,结合文献进行分析。【结果】患者均为中青年女性。表现缺乏特异性,可为头痛呕吐、视物模糊等颅高压症状、癫痫、脑神经瘫痪以及不自主运动等,累及脊髓可致运动感觉及括约肌功能障碍。影像学呈弥漫性浸润病灶。4例患者均侵犯大脑半球3个以上部位并同时侵犯胼胝体,未见明显局灶性占位效应及增强扫描强化。发病早期均被误诊,尤其难与炎症性疾病相鉴别。4例最后均经病理确诊。【结论】弥漫性神经胶质瘤病临床表现缺乏特异性。影像学可帮助诊断,但最终确诊仍需依靠病理检查。【Objective】To investigate the features of the clinical manifestations,image,and pathology of diffuse gliomatosis.【Methods】The clinical data of 4 cases of diffuse gliomatosis with a pathological confirmation was summarized retrospectively and analyzed with a literature review.【Results】All patients were middle-age or young females.The manifestations were not specific including intracranial hypertension symptoms such as headache and vomit,visual blur,seizure,cranial nerve palsy,involuntary movement,and even motor sensory or sphincter dysfunction when the spinal cord was involved.The image findings revealed diffuse infiltrating lesions.All 4 cases constantly offended more than 3 sites of the cerebral hemisphere and simultaneously the corpus callosum,with no obvious mass effect or enhancement.All were misdiagnosed earlier when onset,and were especially difficult to be differentiated from inflammation diseases.All 4 cases were finally pathologically confirmed.【Conclusions】There is no specificity on the clinical manifestations of diffuse gliomatosis.Images are useful in helping the diagnosis,while pathological study is still required to make a definite diagnosis.

关 键 词：弥漫性神经胶质瘤病 临床表现 影像 病理 

分 类 号：R730.26[医药卫生—肿瘤]