环境污染物发育毒性机制研究的系统生物学方法进展  

Review of Systems Biology Approach to Study on Developmental Toxicity Mechanism of Environmental Pollutants

作　　者：徐挺[1,2] 赵静[1] 胡霞林[1] 尹大强[1] 

机构地区：[1]同济大学环境科学与工程学院长江水环境教育部重点实验室,上海200092 [2]安徽大学资源与环境工程学院环境科学研究所,合肥230601

出　　处：《生态毒理学报》2011年第1期23-30,共8页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金(No.20777055);高等学校博士学科点专项科研基金(No.20090072120058)

摘　　要：基因调控网络(gene regulatory network,GRN)是用于研究基因调控的一种新兴的系统生物学方法,尤其适合描述生物体早期发育的调控系统和机制。由于它能体现出调控过程的网络特性和动态关系,从整体的角度全面审视环境扰动所造成的真实影响,因此有望在内分泌干扰物等环境污染物的发育毒性机制研究中发挥重要作用,解决多年来一直困扰相关研究的种种难题。针对基因调控网络的结构、研究方法、应用成果和案例进行综述,并对将这一方法应用于污染物发育毒性机制研究的前景做出展望。Gene regulatory network（GRN） was a novel systematical biology approach for the study on gene regulation mechanism,especially helpful in describing the early development of animal body.Because GRNs can present the networks and dynamics of regulatory processing,and the true impacts from the environmental perturbation,they were expected to play a key role in studying developmental toxicity mechanisms of environmental pollutants including endocrine disrupting chemicals with resolving many problems which existed for a long time.The structures,methodologies,current application cases of GRNs are rewiewed.The application of GRNs into mechanism researches of developmental toxicity of pollutants is previewed in this paper.

关 键 词：基因调控网络 内分泌干扰物 发育毒性 

分 类 号：X171.5[环境科学与工程—环境科学]