米非司酮配伍消结安胶囊治疗子宫肌瘤的远期疗效观察  

Long-term effect of Mifepristone combined with Xiaojie'an capsule on uterine myoma

作　　者：闫印春[1] 

机构地区：[1]山东省菏泽市立医院,山东菏泽274031

出　　处：《中国现代医学杂志》2011年第2期272-274,共3页China Journal of Modern Medicine

摘　　要：目的观察米非司酮配伍消结安胶囊治疗子宫肌瘤的远期疗效。方法将120例子宫肌瘤患者,随机分为两组。米非司酮组60例,每天口服米非司酮12.5 mg,连服3个月;联合用药组(米非司酮+消结安胶囊)60例,每天口服米非司酮12.5mg+消结安胶囊口服每天3次,每次2粒,连服3个月。比较两组治疗期间和停药3个月时的子宫及肌瘤体积和月经恢复情况。结果两组患者临床症状均有明显改善。以子宫肌瘤缩小25.0%以上者为有效,米非司酮组有效率为73.3%,联合用药组有效率为93.3%,两组比较差异有统计学意义(P<0.05)。停药3个月时,联合用药组的月经改善情况和子宫肌瘤变化优于米非司酮组。结论米非司酮配伍消结安胶囊治疗子宫肌瘤时,远期疗效较单用米非司酮更为安全有效,值得在临床推广应用。【Objective】 To observe the long-term effect of a combination of Mifepristone and Xiaojie＇an capsule on uterine myoma.【Methods】 A total of 120 cases of uterine myoma were randomly divided into 2 groups with 60 cases in each group.The patients in Mifepristone group had oral administration of Mifepristone（12.5 mg,po,qd） for 3 consecutive months,while the patients in combination group took both oral Mifepristone（12.5 mg,po,qd） and Xiaojie＇an capsule（2 caps,po,tid） for 3 successive months.The volumes of uterus and myoma,and menstrual restoration were compared between both groups during and 3 months after the therapies.【Results】 The clinical symptoms of both groups were significantly ameliorated.Shrinking of myoma more than 25% was taken as effectiveness.The effective rate in Mifepristone group was 73.3%,while that in combination group was 93.3% with a significant difference（P 0.05）.Three months after the therapies,menstruation improvement and shrinking of myoma were more obvious in combination group than in Mifepristone group.【Conclusion】 For the treatment of uterine myoma,the therapy of combined Mifepristone and Xiaojie＇an capsules is safer and has more prominent long-term effect than usage of Mifepristone alone,and is worth to be popularized in clinic.

关 键 词：子宫肌瘤 消结安胶囊 米非司酮 

分 类 号：R737.33[医药卫生—肿瘤]