肝脏部分切除术在复发性上皮性卵巢癌肝实质转移治疗中的价值  

Significance of hepatic resection in the treatment of hepatic parenchymal metastasis of recurrentepithelial ovarian carcinoma

作　　者：燕鑫[1] 包全[2] 安娜[1] 高雨农[1] 蒋国庆[1] 高敏[1] 郑虹[1] 王文[1] 

机构地区：[1]北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室妇科,100142 [2]北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室肝胆外科

出　　处：《中华肿瘤杂志》2011年第2期132-137,共6页Chinese Journal of Oncology

摘　　要：目的探讨复发性上皮性卵巢癌肝实质转移患者行肝脏部分切除术的临床价值。方法回顾性分析39例复发性上皮性卵巢癌肝实质转移患者的临床病理资料。结果39例患者中，10例进行了肝脏部分切除术，29例仅行挽救性化疗。手术组患者的病变均为单叶，且病灶〈3个，与化疗组比较，差异有统计学意义（P〈0．05），在年龄、初次手术病理类型及病理分级、初次减瘤手术结果、初次治疗后的尤瘤生存时间、肝转移瘤大小及肝转移时CA125水平等方而，差异均无统计学意义（P〉0．05）。10例手术患者中，单纯行肝脏手术6例，同时行其他部位肿瘤细胞减火术4例，其中7例减瘤手术满意。3例发生手术并发症，无手术死亡病例。8例肝脏病理切缘为阴性的患者中，局部复发6例，中位复发时间为术后12个月。减瘤手术满意的患者与行挽救性化疗的患者，肝转移后的中位总生存时间分别为26个月和9个月，肝转移后3年累积生存率分别为60．O％和16．8％，两组比较，差异有统计学意义（P〈0．05）。结论对存在肝实质转移的复发性上皮性卵巢癌患者施行包括肝脏部分切除术在内的满意肿瘤细胞减灭术，术后辅以化疗，有可能改善患者的预后。Objective To investigate the validity of hepatic resection as a treatment option for hepatic parenchymal metastasis in patients with recurrent epithelial ovarian cancer. Methods A retrospective review of the clinicopathological and follow up data of 39 patients treated in our hospital from 1996 to 2008 was conducted. Results Ten patients underwent partial hepatic resection for metastatic ovarian cancer. All the 10 patients underwent surgery were with unilobar metastasis and the number of tumors was, lower than 3 （P 〈 0.05 ）. No significant difference existed in patient age, the primary pathology type and tumor grade, the rate of optimal primary cytoreductive surgery, the disease free survival after the primary therapy and the serum CA125 level at the liver metastasis when compared with the 29 patients accepted salvage chemotherapy （ P 〉 0.05 ）. There were 7 patients who achieved optional surgery. The operation complication was 3/10 and there was no perioperative mortality. There were 2 patients without postoperative chemotherapy in the 8 recurrent patients with microscopic negative margins. The median recurrence time was 12 （5-24） months after the hepatic resection. The overall median survival periods after hepatic metastasis were 26 and 9 months and the 3-years cumulative survival rates were 60.0% and 16.8% for the optimal surgery patients including hepatic surgery and the salvage chemotherapy patients, respectively （ P 〈 0.05 ）. Conclusion Hepatic resection for liver metastatic epithelial ovarian cancer is safe and may achieve long-term survival in patients after optimal second cytoreductive surgery.

关 键 词：卵巢肿瘤 复发 肝转移 肝脏手术 化疗 

分 类 号：R737.31[医药卫生—肿瘤]