国产泮托拉唑治疗非甾体消炎药相关性溃疡出血的疗效分析  

The efficacy analysis of domestic pantoprazole in the treatment of non-steroidal anti-inflammatory drugs associated ulcer bleeding.

作　　者：黄宣[1] 吕宾[1] 张烁[1] 徐毅[1] 

机构地区：[1]浙江中医药大学附属第一医院消化科,310006

出　　处：《中华消化杂志》2011年第1期36-39,共4页Chinese Journal of Digestion

摘　　要：目的比较泮托拉唑（商品名：泮立苏）与奥美拉唑（商品名：洛赛克）治疗非甾体消炎药相关消化性溃疡伴出血的疗效、不良反应及成本-效果比。方法选择符合非甾体消炎药相关性溃疡伴出血诊断标准的住院患者58例，按随机数字表分为泮托拉唑组（31例）和奥美拉唑组（27例）。泮托拉唑组予以国产泮托拉唑40mg加入0．9％氯化钠溶液100ml中静脉滴注，每12小时1次；奥美拉唑组予以进口奥美拉唑40mg加入0．9％氯化钠溶液100ml中静脉滴注，每12小时1次，两组疗程均为7d。观察两组疗效及不良反应，并运用药物经济学方法分析二者成本一效果比。结果泮托拉唑组总有效率为93．5％，奥美拉唑组总有效率为96．3％，两组药物均能有效止血，差异无统计学意义（P=1．00）；两组不良反应发生率分别为3．2％和7．4％；成本-效果比（C／E）分别为7．76、20．73；奥美拉唑相对于泮托拉唑的增量成本-效果比（5C／5E）为454。结论国产泮托拉唑是治疗非甾体消炎药相关性溃疡出血有效、安全、经济的药物。Objective To compare the efficacy, adverse reactions and cost-effectiveness between domestic pantoprazole （Pan Li Su） and imported omeprazole （Losec） in the treatment of non steroidal anti-inflammatory drugs （NSAID） associated ulcer bleeding. Methods Fifty-eight hospitalized patients with NSAID associated ulcer bleeding were randomly divided into pantoprazole group （n = 31） and omeprazole group （n= 27） according to random number table. Pantoprazole group was given 40 mg domestic pantoprazole dissolved 100 ml 0. 9% sodium chloride solution intravenously every 12 hours. Omeprazde group was given 40 mg omeprazole dissolved in 100 ml 0. 9% sodium chloride solution intravenously every 12 hours. The two groups were both treated for seven days. Finally, the efficacy and adverse effect were observed, and cost-effectiveness was analyzed with pharmacoeconomics. Results The total effective rate of pantoprazole group was 93.5 %, omeprazole group was 96.3 % . The drugs of the two groups could effectively stop bleeding, the difference was not statistically significant （P=1.00）. The rate of adverse effect was 3.2% and 7.4% in the two groups accordingly. The cost-effectiveness ratio （C/E） was 7. 76 and 20. 73 respectively. Compared with pantoprazole group, the incremental cost-effectiveness ratio of omeprazole group was 454. Conclusions Domesic pantoprazole is an effective, safety and economical medicine for NSAID associated ulcer bleeding.

关 键 词：消炎药 非甾类 消化性溃疡出血 苯咪唑类 奥美拉唑 费用效益分析 

分 类 号：R573.1[医药卫生—消化系统]