植物状态患者的脑氢质子磁共振波谱分析  

Brain Proton Magnetic Resonance Spectroscopy in Vegetative State

作　　者：严肃[1,2] 崔恒武[1] 张联合[2] 狄海波[3] 李景琦[4] 

机构地区：[1]江苏大学临床医学院,江苏镇江212013 [2]武警浙江总队杭州医院放射科 [3]杭州师范大学基础医学部 [4]武警浙江总队杭州医院康复科

出　　处：《实用放射学杂志》2011年第2期157-160,共4页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目（编号：30870861）.

摘　　要：目的探讨氢质子磁共振波谱（proton magnetic resonance spectroscopy，1H—MRS）技术在植物状态（vegetativestate，VS）临床诊断和预后评估中的价值。方法对20例VS患者和20例年龄匹配的健康志愿者（对照组）行常规MRI检查，并同时行’H—MRS检查，测定双侧额顶叶皮质、白质和丘脑的NAA／Cr、Cho／Cr、NAA／Cho比值。结果1H—MRS示VS患者的双侧额顶叶皮质、白质和丘脑非直接受损部位的NAA／Cr、NAA／Cho值与正常对照组比较均有显著性差异（P〈O．05）；VS组1H—MRS大多出现Lac的异常表现。结论1H—MRS可以对VS患者脑部损伤程度和损伤范围提供客观的参考指标。Objective To investigate the value of proton magnetic resonance spectroscopy （1H--MRS） in the diagnosis and prognosis of vegetative state （VS）. Methods Conventional MRI and 1 H--MRS were performed in 20 age--matched normal volunteers and 20 patients with VS. The ratios of NAA/Cr,Cho/Cr,NAA/Cho in grey,white matter of the frontoparietal lobe and thalamus were quantified using 1H- MRS. Results The ratios of NAA/Cr and NAA/Cho in grey and white matter of the bilateral frontopari- etal lobe and thalamus were of significantly different between VS group and normal contrals（P〈0.05）. Lac peak appeared in most VS patients. Conclusion 1H--MRS can provide objective referential indexes for the trauma extent and range in VS.

关 键 词：脑 氢质子磁共振波谱 植物状态 创伤性脑损伤 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]