丙氨酰谷氨酰胺二肽对早期断奶仔猪抗氧化能力及肠道保护的研究  

Studies on Alany-glutamine on Antioxidant Ability and Protects of Small Intestine for Early Weanling Piglets

作　　者：陈恒灿[1] 马黎[2] 陈克嶙[1] 谭丽勤[1] 袁雪波[1] 郭荣富[1] 

机构地区：[1]云南农业大学云南省动物营养与饲料重点实验室,昆明650201 [2]云南农业职业技术学院,昆明650212

出　　处：《畜牧兽医学报》2011年第2期251-259,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：云南省教育厅科学研究基金项目(08y0396)

摘　　要：本试验旨在研究丙氨酰谷氨酰胺二肽（Ala-Gln）对早期断奶仔猪抗氧化能力和肠道保护的影响。采用完全随机化设计,选用体质量、胎次、泌乳量、产仔数相近、健康的云南撒坝母猪所产的48头仔猪（1/2♂,1/2♀）,35日龄断奶,随机分成4个处理,每个处理3个重复,每个重复4头。A组为对照组,饲喂基础日粮,B、C和D组分别饲喂添加0.15%、0.30%和0.45%Ala-Gln的试验日粮。试验期为35~60日龄。结果表明,添加0.15%、0.30%和0.45%Ala-Gln可提高断奶仔猪生长性能,随饲粮Ala-Gln添加水平提高,日采食量、体质量呈二次曲线上升（P〈0.05）,料重比呈二次曲线降低（P〈0.05）。第49日龄的仔猪血清T-AOC和T-SOD含量以二次曲线方式升高（P〈0.05）,血清MDA活性呈二次曲线降低（P〈0.01）。小肠形态学观察结果显示,仔猪十二指肠和回肠绒毛长度以二次曲线方式升高（P〈0.01）,空肠绒毛长度以二次曲线方式升高（P〈0.05）,十二指肠和空肠隐窝深度以二次曲线方式降低（P〈0.05）,十二指肠、空肠和回肠绒毛长度和隐窝深度比值（V/C）以二次曲线方式提高（P〈0.01）。结果提示,引入外源Ala-Gln可以改善撒坝仔猪生长潜力,增强早期断奶仔猪的抗氧化能力,保护肠道结构与功能发育。This experiment was conducted to investigate the effects of Alany-glutamine（Ala-Gln） on antioxidant ability and protecting intestine of early weanling piglets.48 piglets of weanling at 35 days（half male,half female）,reproduced by Yunnan Saba sows with similar body weight,parity,milk yields and litter size,were designed randomly to 4 groups,each has 3 repeats with 4 piglets per repeat.Group A（control） was fed the basal diet,and experimental diets with adding 0.15%,0.30% and 0.45% for group B,C and D,respectively.The duration of experiments was from 35 to 60 days.The results indicated that growth performance of piglets can be improved with Ala-Gln supplementation of 0.15%,0.30% and 0.45%,respectively.With the increase of dietary Ala-Gln supplementation,body weight and daily feed intake for piglets were increased（P0.05） and feed：gain was decreased as a quadratic function（P0.05）.At the 49th day,the serum T-AOC and SOD concentrations were increased（P0.05）,and the serum MDA contents was decreased as quadratic equation（P0.01）.The results of intestinal morphology determination showed that the length of duodenum and ileum villus for piglets increased as quadratic equation（P0.01）,and length of jejunum villus increased as a quadratic function（P0.05）,duodenal and jejunal crypt depth reduced as the quadratic function（P0.05）,ratio（V / C） of duodenum,jejunum and ileum villus length to crypt depth can be improved as the quadratic manner（P0.01）.It was concluded that the growth performance and antioxidant ability of Saba weanling piglets can be improved,and intestine structures and functional development can be protected with adding dietary Ala-Gln.

关 键 词：早期断奶仔猪 丙氨酰谷氨酰胺二肽 抗氧化能力 小肠形态学 肠道保护 

分 类 号：S852.4[农业科学—基础兽医学] S828[农业科学—兽医学]