炎症影响药物转运体表达及活性研究进展  

Progress and research about effects of inflammation on expression and activity of drug transporters

作　　者：高利臣[1] 张伟[1] 范岚[1] 周宏灏[1] 

机构地区：[1]中南大学临床药理研究所,遗传药理学湖南省重点实验室,湖南长沙410078

出　　处：《中国药理学通报》2011年第1期7-10,共4页Chinese Pharmacological Bulletin

基　　金：国家重大新药创制专项资助(No2009ZX09304-003,2009ZX09501-032);国家自然科学基金资助项目(No30801421,30901834);中南大学基本科研业务重点项目(No2010QZZD010)

摘　　要：伴随机体炎症因子大量释放,药物转运体表达及活性发生了改变,进而影响了药物吸收、分布、转化及消除过程,这会使药物产生毒性或疗效变化,亦会导致药物—药物相互作用发生。该文就炎症相关因素影响药物转运体表达、活性、可能机制及临床应用最新研究进展进行综述,以期为炎症调节转运体研究指明方向。The expression and activity of some drug transporters are regulated by inflammatory factor during its release.Concomitantly,the processes of drug absorption,distribution,transformation and elimination are also influenced.After that,the drug toxicity occurs or drug efficacy decreases,which even leads to drug-drug interactions.This review summarizes the possible mechanisms,clinical application and effects of inflammation on expression and activity of drug transporters to guide the direction for its further research.

关 键 词：炎症诱导物 促炎细胞因子 抗炎药物 药物转运体 调节机制 临床应用 

分 类 号：R-05[医药卫生] R364.5