鸡胚氧化应激模型研究进展  

Research progress on oxidative stress models of chicken embryo

作　　者：李小迪[1] 覃杨[1] 何蓉蓉[1] 栗原博[1] 

机构地区：[1]暨南大学中药及天然药物研究所,广东广州510632

出　　处：《中国药理学通报》2011年第1期15-19,共5页Chinese Pharmacological Bulletin

基　　金：暨南大学211工程基金资助课题(No20081118)

摘　　要：鸡胚作为经典的发育学模型,广泛应用于生物学的各个领域。胚胎在发育过程中对外界刺激敏感,其中氧化应激是导致早期胚胎发育损伤的机制之一。已有研究利用各种应激原负荷建立不同的鸡胚氧化应激模型,用于探讨氧化应激对胚胎发育的不良影响,研究疾病的发生机制,筛选和评价药物的活性。该文对鸡胚氧化应激模型的研究进展加以综述,为今后的相关研究提供参考。Chicken embryo as a typical developmental model is widely used in biological studies.The embryo is most sensitive to environmental oxidative stress and excess ROS is strongly associated with embryotoxicity.The oxidative stress models of chicken embryo based on different stressors not only can be used for exploring the relationships between stress and embryo development,studying the mechanisms of diseases,but also for screening and evaluating the activities of antioxidants.This review summarized and introduced the related mechanisms of chicken embryo models to provide beneficial references about oxidative stress for the future researches.

关 键 词：鸡胚 发育 凋亡 自由基 氧化应激 模型 

分 类 号：R-05[医药卫生] R321-33