兔晶状体超声乳化后囊膜混浊模型的建立与观察  

Establishment and observation of animal model of posterior capsule opacification in rabbits

作　　者：黄文丽[1] 蒋永祥[2] 吕志刚[1] 

机构地区：[1]浙江省金华市中心医院眼科,金华321000 [2]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《中国眼耳鼻喉科杂志》2011年第1期13-15,70,共4页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：中国科学院金华科技园专项基金项目(2006-3-005)

摘　　要：目的建立一种微创、安全、有效、快速的兔晶状体超声乳化后囊膜混浊模型,为更高要求的实验作准备。方法新西兰大白兔11只(22只眼),行双眼超声乳化术,分别于术后1d、3d、1周、2周和术后1、2、3个月对术眼进行裂隙灯显微镜及组织病理学检查,观察兔眼前、后节反应,后囊膜混浊形成时间、部位、发展过程及组织形态学改变。结果后囊膜混浊由周边部向中央区发展,伴Elschnig小体和晶状体纤维生成,其程度随时间推移日渐加重;术后3个月均出现不同程度的后囊膜混浊。结论成功建立兔晶状体超声乳化后囊膜混浊模型,可为更高要求研究后囊膜混浊的实验做准备。Objective To establish an animal model of posterior capsule opacification （PCO） with clear corneal tunnel phacoemulsification technique in rabbits. Methods Clear corneal tunnel phacoemulsifications were perfomed in 22 eyes of 11 New Zealand rabbits. The operative eyes were examined at 1 day, 3 days, 1 week, 2 weeks and 1 month,2 months, 3 months postoperatively by slitlamp microscope and histopathological method respectively to observe the time location, development and histomorphological changes of PCO formation. Results The posterior capsule opacity deve loped from the periphery to the central area with Elschnig peals and lens fibers formation, the degree of which grew worse with the extension of time. PCO appeared in all eyes 3 months after the surgery. Conclusions The PCO animal model with clear corneal tunnel phacoemulsification technique was successfully established in rabbits. （Chin J Ophthalmol and Otorhinolaryngo1,2011,11： 13-15）

关 键 词：超声乳化 后囊膜混浊 白内障 

分 类 号：R779.66[医药卫生—眼科]