野生和人工繁育树鼩部分生理指标检测与比较  

Detection and comparison of physiological indexes in the wild and laboratory tree shrew

作　　者：马旭通[1,2] 李福林[3] 蒋宏君[3] 李文辉[1] 张云[1] 杜廷义[1,3,2] 

机构地区：[1]中国科学院和云南省动物模型与人类疾病机理重点实验室中国科学院昆明动物研究所,云南昆明650223 [2]中国科学院研究生院,北京100049 [3]云南省第一人民医院检验科,云南昆明650032

出　　处：《Zoological Research》2011年第1期4-10,共7页动物学研究（英文）

基　　金：中国科学院知识创新工程重要方向项目(KSCX2-EW-R-11);中国科学院基础前沿研究专项项目(KSCX2-EW-J-23);中国科学院和云南省动物模型与人类疾病机理重点实验室资助项目

摘　　要：比较野生和人工繁育树鼩的部分生理指标,为人类疾病的动物模型创制提供基本参数。血液采自昆明地区54只野生树鼩(被捕获后人工饲养1—2月)和54只子一代人工繁育树鼩。该研究首次报道在两组动物中,肌酸激酶、肌钙蛋白I、总胆汁酸、果糖胺、低密度脂蛋白胆固醇等在性别间差异无显著性;这些指标在人工繁育树鼩中的中位数(四分位数间距)依次为:1449(956)U/L、5.94(7.23)μg/L、15.6(19.7)μmol/L、393.5(80.8)μmol/L和0.36(0.32)mmol/L;在野生树鼩中依次为:986(564)U/L、4.01(4.10)μg/L、20.0(20.6)μmol/L、379.0(104.0)μmol/L和0.46(0.23)mmol/L。人工繁育树鼩生理指标表现出个体间离散程度降低趋势,但个别反映肝脏功能及心肌情况的指标表现出平均值上升,个体离散程度扩大的现象。这些生理指标为人类疾病的树鼩模型创制打下了基础。To provide fundamental basis for the tree shrew models of human diseases, we examined and compared the physiological and biochemical indexes between wild and laboratory tree shrews. Blood samples were taken from 54 wild tree shrews that were housed in laboratory for 1 - 2 months, and from 54 first-generation of the laboratory tree shrews; each group had nearly equal male and female composition. Some of the first reported physiological and biochemical indexes were showed no significant differences between genders, and these indexes in laboratory tree shrews were as follows [medium （inter-quartile range） ]： CK 1449 （956） U/L, CTNI 5.94 （7.23） μg/L, TBAIS.6 （19.7） μmol/L, FRUC 393.5 （80.8）/amol/L and LDL-C0.36 （0.32）; and in the wild tree shrews, 986 （564） U/L, 4.01 （4.10） μg/L, 20.0 （20.6） p.mol/L, 379.0 （104.0） μmol/L and 0.46 （0.23） mmol/L, respectively. In the laboratory tree shrews, the variations of physiological and biochemical indexes were smaller, but the mean values of some indicators related to liver and heart functions became higher. These data would be valuable for the development of tree shrew models of human diseases.

关 键 词：野生树鼩 人工繁育树鼩 血液样本 生理指标 比较 

分 类 号：R735.7[医药卫生—肿瘤]