平阳霉素碘油乳剂超选择硬化性栓塞治疗肝血管瘤  

Superselective embolization with Pingyangmycin lipiodol emulsion for the treatment of liver cavernous hemangioma

作　　者：孔鹏[1] 鹿化伟 王家平[1] 闫东[1] 李迎春[1] 孙敏[1] 谭晶[1] 童玉云[1] 滕云山[1] 

机构地区：[1]昆明医学院附属第三临床医院介入科孔,650101 [2]泰安医学院

出　　处：《介入放射学杂志》2011年第2期123-126,共4页Journal of Interventional Radiology

摘　　要：目的总结平阳霉素碘油乳剂行肝动脉硬化栓塞术(TAE)治疗的肝血管瘤的疗效和优缺点。方法对150例肝血管瘤患者,采用平阳霉素碘油乳剂超选择性动脉插管行硬化栓塞治疗,观察治疗前和治疗后3、6个月时患者临床症状、肿瘤大小的变化以及出现的并发症。结果所有患者在术后3、6个月复查CT,见瘤体血供消失,其内碘油沉积良好,并出现瘤体缩小、碘化油聚积征象。术前血管瘤直径平均(8.47±2.27)cm,术后3、6个月血管瘤直径分别平均(5.75±1.40)cm和(3.51±0.82)cm(P<0.05)。治疗前有临床症状者治疗后缓解或消失。术后均未出现胆囊坏死、胆管狭窄和肝坏死等严重并发症。结论肝动脉平阳霉素碘油乳剂栓塞治疗肝血管瘤是一种安全、有效、微创的非手术治疗方法。治疗效果明显,其硬化性栓塞与药理作用是一种较为理想的栓塞方案。Objective To evaluate the advantages and disadvantages of superselective embolization therapy with Pingyangmycin lipiodol emulsion in treating liver cavernous hemangiomas.Methods One hundred and fifty patients with hepatic cavernous hemangioma underwent superselective hepatic artery embolization treatment with Pingyangmycin lipiodol emulsion.The changes of clinic symptoms and tumor volumes,and the occurrence of complications were observed both before treatment and at 3 and 6 months after treatment.Results CT scans showed that the blood supply of the tumor disappeared at 3 months and 6 months after treatment,and tumor volume was reduced in all patients.The lipiodol deposited well within the tumor in all patients.The mean tumor diameter was（8.47 ± 2.2 7）cm before intervention,which decreased to（5.75 ± 1.40）cm（P 0.05） at 6 months after treatment and to（3.51 ± 0.82）cm at 12 months after treatment.The clinic symptoms were alleviated or even disappeared in all patients.No severe complications such as gallbladder injury,bile duct stenosis or hepatic necrosis occurred during and after the therapy.Conclusion Superselective embolization therapy with Pingyangmycin lipiodol emulsion is an effective,safe and minimally-invasive non-surgical treatment for liver cavernous hemangiomas.With satisfactory clinical results,this technique can be regarded as an ideal embolization therapy.

关 键 词：肝血管瘤 栓塞 平阳霉素 

分 类 号：R735.7[医药卫生—肿瘤]