索拉非尼治疗晚期肝癌不良反应的观察和护理  

The observation and nursing for advanced hepatocellular carcinoma patients treated with Sorafenib

作　　者：陈瑜[1] 徐静[1] 林福群[1] 

机构地区：[1]浙江省温州医学院附属第一医院介入科,325000

出　　处：《介入放射学杂志》2011年第2期156-158,共3页Journal of Interventional Radiology

摘　　要：目的总结索拉非尼治疗晚期肝癌不良反应的观察和护理体会。方法通过回顾索拉非尼治疗的34例晚期肝癌患者治疗期间的不良反应及程度,治疗过程和护理措施,总结经验。结果本组34例患者发生不同程度的不良反应,包括中性粒细胞减少、足手综合征、疲劳、腹泻、高血压、皮疹等。其中足手综合征4级1例、3级3例,中性粒细胞减少3级1例,予以减量后症状缓解。结论熟悉索拉非尼的剂量、不良反应,严密观察患者的不良反应,提供适当的护理,可提高治疗疗效和病人生活质量。Objective To summarize the author＇s experience which was obtained in observing and nursing the adverse reactions of advanced hepatocellular carcinoma patients who were treated with Sorafenib.Methods The adverse reactions and their severity observed in 34 patients with advanced hepatocellular carcinoma who were treated with Sorafenib were retrospectively analyzed.Results Side effects or toxic reaction were observed in all the patients,which included neutropenia,foot-hand syndrome（FHS）,fatigue,diarrhea,hypertention,rash,etc.Five patients had to cut down the dose of Sorafenib in order to relieve the symptom,among them one patient had grade 4 FHS,3 patients had grade 3 FHS and one patient had grade 3 neutropenia.Conclusion Being familiar with sorafenib＇s adverse reaction,closely observing the patients condition and affording appropriate nursing measures,all the above items can definitely improve the therapeutic results and patient＇s living quality.

关 键 词：索拉非尼 晚期肝癌 不良反应 护理 

分 类 号：R735.7[医药卫生—肿瘤] R473.73[医药卫生—临床医学]