磁共振氢质子波谱鉴别软组织肿瘤良恶性的价值  

Value of ~1H-MRS in differentiation of soft tissue tumors

作　　者：王李[1] 宋岫峰[1] 李月罡[1] 刘长剑[2] 王绍武[2] 

机构地区：[1]大连市友谊医院医学影像科,辽宁大连116001 [2]大连医科大学附属第一医院放射科,辽宁大连116003

出　　处：《中国介入影像与治疗学》2011年第2期121-124,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨1H-MRS在软组织肿瘤定性诊断中的应用价值。方法收集经手术及病理证实的12例良性和10例恶性软组织肿瘤患者,分析其1H-MRS各代谢物浓度比值(Cho/Cr、Cho/NAA、Cr/NAA)及其相关性。结果①恶性和良性软组织肿瘤Cho/Cr比值分别为3.72±2.76、0.88±0.53,差异有统计学意义(P<0.05),Cho/NAA和Cr/NAA差异均无统计学意义(P均>0.05)。②良性软组织肿瘤Cr浓度与Cho及NAA浓度均呈正相关(r=0.884、0.822,P均<0.01),其余代谢物浓度间均无相关性(P均>0.05)。③恶性软组织肿瘤Cr浓度与NAA浓度呈正相关(r=0.952,P<0.001),其余代谢物浓度间均无相关性(P均>0.05)。结论 Cho/Cr比值可作为良、恶性软组织肿瘤鉴别诊断的重要依据。Cho/Cr比值升高提示软组织肿瘤为恶性可能性大;Cho/Cr比值降低提示软组织肿瘤为良性可能性大。Objective To investigate the value of 1H-MRS in diagnosis of soft tissue tumors.Methods Twelve patients with benign（benign group） and 10 with malignant（malignant group） soft tissue tumors convinced with pathology were reviewed.The correlations among 1H-MRS metabolites were analyzed,and their ratio were compared between benign and malignant groups.Results The ratio of Cho/Cr was 3.72±2.76 in malignant group and 0.88±0.53 in benign group（P0.05）.No difference of Cho/NAA,Cr/NAA was found between the two groups（both P0.05）.In benign group,Cr was positively correlated with Cho and NAA（r=0.884、0.822,both P0.01）,and no correlation was found between other metabolites（all P0.05）.In malignant group,value of Cr and NAA was positively relative（r=0.952,P0.001）,and no correlation was found between other metabolites（all P0.05）.Conclusion The ratio of Cho/Cr is of important value in distinguishing benign and malignant soft tissue tumors.High value of Cho/Cr means greater possibility of malignant soft tissue tumors and low value of Cho/Cr means greater possibility of benign soft tissue tumors.

关 键 词：软组织肿瘤 磁共振波谱学 

分 类 号：R738[医药卫生—肿瘤]