卵磷脂胆固醇酰基转移酶基因608C／T和511C／T多态性与湖南地区汉族人卒中的关系  

Relationship between polymorphisms of lecithin cholesterol acyltransferme gene 608C/T or 511C/T and stroke in Chinese Han population in Hunan province

作　　者：朱晓岩[1] 侯荣耀[2] 许宏伟[3] 王玉春[1] 肖波[3] 杨期东[3] 唐北沙[3] 

机构地区：[1]青岛大学医学院附属海慈医院ICU,266033 [2]青岛大学医学院附属海慈医院神经内科,266033 [3]中南大学湘雅医院神经内科,长沙410011

出　　处：《国际脑血管病杂志》2011年第1期63-68,共6页International Journal of Cerebrovascular Diseases

基　　金：基金项目：国家自然科学基金（30370514）

摘　　要：目的探讨卯磷脂胆固醇酰基转移酶（lecithincholesterolacyltransferase，LCAT）基因608C／T和511C／T多态性与中国湖南地区汉族人群卒中发病的关系。方法选择150例脑梗死、150例脑出血患者以及122名年龄和性别相匹配的对照者，应用聚合酶链反应、单链构象多态性技术和限制性片段长度多态性技术检测LCAT基因608C／T和511Cff多态性。结果脑梗死组LCAT基因608C／TCT基因型频率（14．0％）和T等位基因频率（7．0％）均显著高于对照组（P均〈0．01），而脑出血组CT基因型频率（7．3％）和T等位基因频率（3．7％）与对照组无显著差异（P〉0．05）；脑梗死组I．CAT基因511C／TCT基因型频率（10．0％）和T等位基因频率（5．0％）均显著高于对照组（P均〈0．01），而脑出血组CT基因型频率（3．3％）和T等位基因频率（1．7％）与对照组无显著差异（P〉0．05）。结论LCAT基因608C／T和511C／T多态性可能与中国湖南地区汉族人群动脉粥样硬化性脑梗死发病有关，可能为该人群动脉粥样硬化性脑梗死的易感因素，而与脑出血发病无关。Objective To explore the relationship between lecithin cholesterol acy ltransferase （LCAT） gene 608C/T and 511C/T polymorphisms and stroke in Chinese Han population in Hunan province. Methods One hundred fifty patients with cerebral infarction, 150 patients with cerebral hemorrhage, and 122 age- and sex-matched healthy controls were selected. LCAT gene 608C/T and 511C/T polymorphisms were detected by using polymerase chain reaction, single strand conformation polymorphism, and restriction fragment length polymorphisms. Results The CT genotype frequency （14. 0% ） and T allele frequency （7. 0% ） of the LCAT gene 608C/T in the cerebral infarction group were significantly higher than those in the control group （all P 〈0. 05）, while there were no significant differences in the CT geotype frequency （7. 3% ） and T allele frequency （3.7%） between the cerebral hemorrhage group and the control group （P〉0. 05）. The CT genotype frequency （10. 0%） and T allele frequency （5.0%） of the LCAT gene 511C/T in the cerebral infarction group were significantly higher than those in the control group （all P 〈0. 01）, while there were no significant differences in the CT genotype frequency （3.3%） and T allele frequency （1.7%） between the cerebral hemorrhage group and the control group （P 〉0. 05）. Conclusions The 608C/T and 511CFF polymorphisms may be associated with the occurrence of atherosclerotic cerebral infarction in Chinese Han population in Hunan province. They may be the predisposing factors for atherosclerotic cerebral infarction in this population; however, they are not associated with cerebral hemorrhage.

关 键 词：磷脂酰胆碱-甾醇O-酰基转移酶 卒中 脑梗死 脑出血 动脉粥样硬化 多态现象 遗传学 

分 类 号：R74[医药卫生—神经病学与精神病学]