碘、钼、硒、镁、硼预防小鼠氟斑牙效果的评价  

The evaluation of dental fluorosis prevention with the application of iodine,molybdenum,selenium,mag-nesium and boron in mice

作　　者：陶洪[1] 郭海燕[2] 侯铁舟[3] 刘青[3] 

机构地区：[1]西安交通大学医学院第一附属医院口腔科,西安710061 [2]山西省儿童医院口腔科,太原030013 [3]西安交通大学口腔医院牙体牙髓病科,西安710004

出　　处：《国际口腔医学杂志》2011年第2期145-149,共5页International Journal of Stomatology

基　　金：西安市社会发展基金资助项目(SF200227)

摘　　要：目的通过观察微量元素碘、钼、硒、镁、硼预防小鼠氟斑牙的效果,筛选较优的抗氟元素。方法将170只雄性ICR小鼠随机分为17个组:空白组饮用双蒸水,氟组饮用含110 mg.L-1NaF的双蒸水,15个微量元素组分别将碘化钾、钼酸钠、亚硒酸钠、四硼酸钠、硫酸镁按照各自化合物半数致死剂量(LD50)的25%、50%、75%三个剂量添加于饲料中,饮水同氟组。通过观察小鼠体重及牙长增长率,氟斑牙形成的时间、形成时分级及D42分级,确定较优的抗氟元素。结果 5种微量元素均具有一定预防氟斑牙的作用,硫酸镁及四硼酸钠LD50的25%剂量显示出较好的预防效果。结论镁、硼是具有较好抗氟效果的微量元素。Objective To screen the better anti-fluorine microelement through adding iodine,molybdenum,se-lenium,magnesium and boron in feed and observing the mitigatory degree of dental fluorosis.Methods 170 male ICR mices were randomly separated to 17 groups.The blank group drank the distilled water.Fluorine group drank the distilled water containing sodium fluoride 110 mg·L-1.Both of them were common feed.Sodium fluoride was also given to mice in drinking water in 15 microelement groups.Kalium iodidum were added into feed with the dosage based on the 25%,50%,75% of compound LD50.Sodium molybdatesodium,sodium selenite,sodium te-traborate,magnesium sulfate were added into feed in the same way.The growth rate of body weight and tooth length,formative time of dental fluorosis,formative grade and final grade of dental fluorosis were observed.Results All of the five microelements can prevent the dental fluorosis in varying degrees.MgSO4 and Na2B4O7 with the dosage of 25% compound LD50 in feed show better preventive effect than others.Conclusion Magnesium and boron are potenial microelements that has anti-fluorine effect.

关 键 词：氟斑牙 微量元素 拮抗作用 

分 类 号：R780.1[医药卫生—口腔医学]