安氏Ⅱ~2类错家庭聚集性与遗传度研究  

Familial aggregation and heritability of class Ⅱ~2 malocclusion

作　　者：陈允嘉[1] 王豫蓉[1] 邹林洪[1] 李艳[1] 郑雷蕾[1] 吴艳[1] 秘双燕[1] 吴增波[1] 王强[1] 

机构地区：[1]重庆医科大学附属口腔医院正畸科,400015

出　　处：《重庆医学》2011年第9期838-839,842,共3页Chongqing medicine

基　　金：重庆市卫生局重点课题资助项目(2009-1-32)

摘　　要：目的通过安氏Ⅱ2类错家庭聚集性分析研究以及安氏Ⅱ2类错遗传度估算,探讨遗传因素在安氏Ⅱ2类错致病机制中的地位。方法采用遗传流行病学病例对照的方法,对126例安氏Ⅱ2类错先证家系及150例对照家系进行对照研究,比较一级亲属患病率。结果先证组一级亲属总的患病率为25.37%,明显高于对照组一级亲属总患病率(6.60%),患病病例分布的理论频数与实际频数比较差异有统计学意义(P<0.05),一级亲属遗传度估算值为92.26%。结论安氏Ⅱ2类错的发生具有家庭聚集性,遗传因素在该病致病机制中占有重要地位。Objective To explore the role of genetic factor in class Ⅱ2 malocclusion.Methods 276 pedigrees,including 126 class Ⅱ2 malocclusion pedigrees and 150 control pedigrees,were investigated in Chongqing area.Familial aggregation was evaluated by binominal analysis.Results The prevalence rate of class Ⅱ2 malocclusion in first-degree relatives was 25.37%,significantly higher than 6.06% of control pedigrees.The results from binominal distribution analysis showed that actual frequency of class Ⅱ2 cases were significantly higher than that of theoretical frequency（P0.05）,which indicated that there was significant familial aggregation in the occurrence of class Ⅱ2 malocclusion.The estimated value of control pedigrees was 92.26%.Conclusion Class Ⅱ2 malocclusion shows significantly familial aggregation.Genetic factors play an important role in the incidence of class Ⅱ2 malocclusion.

关 键 词：错 安氏Ⅱ类 家庭聚集性 遗传度 

分 类 号：R783.5[医药卫生—口腔医学]