饮酒与三种转氨酶关系的探讨  

Relationship between alcohol consumption and hepatic enzymes

作　　者：高蓓[1] 许铠 殷建忠[1] 付强[1] 王琦[1] 张雪辉[1] 吴少雄[1] 

机构地区：[1]昆明医学院公共卫生学院营养与食品科学系,云南昆明650031 [2]红河州第一人民医院,云南红河661100

出　　处：《中华疾病控制杂志》2011年第3期222-224,共3页Chinese Journal of Disease Control & Prevention

基　　金：达能营养中心膳食营养研究与宣教基金(DIC2008-13)

摘　　要：目的探讨长期饮酒人群中酒精摄入量与丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)三种转氨酶的关系。方法采用自行编制的调查问卷对云南省楚雄彝族自治州的彝族居民进行饮酒行为调查,根据纳入标准(平均每周饮酒次数≥3次或平均每次饮酒折合成高度白酒2.5两或以上),按照随机原则在以上饮酒者中选取124人,对其生化指标进行分析。结果平均酒精摄入量与饮酒者的log ALT(r=0.378,P<0.01)、log AST(r=0.406,P<0.01)、log GGT(r=0.468,P<0.01)水平均呈正相关;按不同酒精摄入量分组,各组在三项转氨酶水平上差异有统计学意义,随着酒精摄入量的增加,三项转氨酶水平也随之增高。结论肝细胞转氨酶水平与酒精摄入量有一定的关系,因此对长期饮酒者进行血清转氨酶检测有着重要意义。Objective To explore the relationship between alcohol intake level and the hepatic enzymes（ALT,AST,GGT） in people who drinks.Methods Yi residents of three townships were selected and investigated with questionnaire on their drinking behaviors by face to face.Then 124 drinkers were picked out according to the screening criteria-the drinking frequency per week was over 3 times,or the average drinking amount each time was no less than 125 g,and their hepatic enzyme levels were measured.Results Alcohol consumption had a positive correlation with log ALT（r=0.378,P0.01）,log AST（r=0.406,P0.01） and log GGT（r=0.468,P0.01）.There were significant differences between drinkers of different groups on alcohol intakes on serum ALT,AST and GGT levels.Conclusions There has a certain relationship between alcohol intake level and the hepatic enzymes in drinkers,and it is of great significance for detection of serum transaminase.

关 键 词：饮酒 问卷调查 流行病学研究 

分 类 号：R181[医药卫生—流行病学]