3-羟基-2-萘醛缩氨基硫脲稀土配合物的合成及其与DNA的相互作用  

Synthesis and Interaction with ct-DNA of 3-Hydroxy-2-naphthaldehyde Thiosemicarbazide and Its Rare Earth Complexes

作　　者：杨欢春[1,2] 杨天林[1] 王丽娟[1] 

机构地区：[1]宁夏大学能源化工重点实验室,宁夏银川750021 [2]宁夏疾病预防控制中心,宁夏银川750001

出　　处：《中国医药工业杂志》2011年第3期170-174,共5页Chinese Journal of Pharmaceuticals

基　　金：教育部科学基金重点项目(208159);宁夏高校科学研究基金资助项目

摘　　要：合成了3-羟基-2-萘醛缩氨基硫脲及其稀土配合物,通过IR、UV、元素分析、摩尔电导及热分析等进行了结构表征。在pH 7.22的Tris-HCl缓冲液中,采用紫外光谱、荧光光谱和黏度法研究了目标化合物与ct-DNA的相互作用。结果表明该化合物以插入式与ct-DNA键合。The Schiff base of 3-hydroxy-2-naphthaldehyde with thiosemicarbazide and its rare earth complexes were synthesized.The structure has been characterized by IR,UV,TG-DTA,elements analysis and molar conductance analysis.The interaction between its complexes and ct-DNA has been studied by electronic absorption spectroscopy,fluorescence spectroscopy,viscosity measurement in buffer solution of Tris-HCl（pH 7.22）.All of the results indicated that the interaction of the complexes with ct-DNA is intercalation.

关 键 词：3-羟基-2-萘醛 氨基硫脲 希夫碱 稀土配合物 合成 

分 类 号：O626[理学—有机化学]