小分子抗癌新药nutlin-3的合成新法研究  

Research of Synthetic Methods to Nutlin-3,a Small Molecules Anticancer Drug

作　　者：陈芬[1] 覃宇[1] 丁四海[1] 

机构地区：[1]武汉职业技术学院生物工程学院,湖北武汉430074

出　　处：《武汉职业技术学院学报》2011年第1期75-78,共4页Journal of Wuhan Polytechnic

摘　　要：以4-甲氧基-2-羟基苯甲醛和对氯苯甲醛为原料,采用7步反应初步合成了小分子抗肿瘤药物nutlin-3,TLC检测每一步反应,总收率40%。对中间体和目标产物的结构和纯度进行了IR和1H NMR表征。Nutlin-3 is A small molecules anticancer drug,synthesized from the starting materials 4-methoxy-2-hydroxybenzaldehyde and its seven steps in chlorobenzaldehyde is listed in this paper.Every step of the reaction was tested by TLC and the total yield was 40%.The structure and purity of intermediate products was characterized by IR and 1H NMR spectra.

关 键 词：Nutlins 咪唑啉类似物 抗肿瘤 合成 表征 

分 类 号：R979.1[医药卫生—药品]