急性白血病化疗后不同时期应用粒细胞集落刺激因子的疗效比较  

Effects comparison of G-csf applied in different periods of acute leukemia after chemotherapy

作　　者：王景[1] 殷献录[1] 李静[1] 

机构地区：[1]安徽省蚌埠市第三人民医院血液科,233000

出　　处：《淮海医药》2011年第2期112-113,共2页Journal of Huaihai Medicine

摘　　要：目的观察急性白血病(AL)化疗后不同时期应用粒细胞集落刺激因子G-CSF的疗效。方法随机选择处于缓解期的急性白血病30例,分为2组,分别在化疗后48 h(治疗组)和中性粒细胞(ANC)<1.0×109/L(对照组)使用粒细胞集落刺激因子,当ANC≥1.5×109/L时停药。观察ANC变化及感染发生率。结果治疗组ANC≤0.5×109/L持续天数,ANC≥1.5×109/L所需天数,使用粒细胞集落刺激因子天数,感染发生率均明显小于对照组(P<0.05),ANC最低值明显高于对照组(P<0.05)。结论急性白血病在化疗后应尽早使用粒细胞集落刺激因子。Objective To observe the effects of G-csf applied in different periods of acute leukemia after chemotherapy.Methods 30 cases in the acute leukemic remission were randomly selected and divided into two groups： control group and treatment group.Then G-csf was applied when the ANC1.0×10~9/L and 48h after chemotherapy respectively until ANC≥1.5×10~9/L.ANC changes and infection rates were observed to evaluate effects of G-csf.Results As for the treatment group,the days of ANC≤0.5×10~9/L lasting,the days reaching ANC≥1.5×10~9/L needed,the days of G-csf used,and the infection rates were all significantly less than the control group（P0.05）.The minimum of ANC was obviously higher than the control group（P0.05）.Conclusion G-csf should be used early after acute leukemia chemotherapy.

关 键 词：粒细胞集落刺激因子 白血病 药物疗法 

分 类 号：R733.7[医药卫生—肿瘤]