恶性肿瘤并发血栓性疾病临床分析  

Clinical analysis of malignant tumor with thrombosis

作　　者：张丽[1] 王燕[2] 曹建存[1] 马力[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津医科大学总医院肿瘤科,天津300052

出　　处：《天津医科大学学报》2011年第1期54-56,共3页Journal of Tianjin Medical University

摘　　要：目的:了解恶性肿瘤合并血栓性疾病的临床和实验室特点。方法:对33例恶性肿瘤合并血栓性疾病患者的临床特点及化疗前血常规、凝血功能等进行回顾性分析。结果:血栓组病例占同期发病的6.1%,且以深部静脉血栓形成(VTE)为主。血栓性疾病可能是恶性肿瘤的首发表现,以血栓事件起病的恶性肿瘤中44.4%已发生远处转移。恶性肿瘤血栓组1年及1年半生存时间较非血栓组短(P<0.05)。血栓组和非血栓组相比,抗肿瘤治疗前血小板、白细胞、凝血酶原时间(PT)及D-D(DD)水平存在显著差异(P<0.05)。结论:伴有血小板、白细胞和DD升高的恶性肿瘤患者,更易发生血栓事件,预后差,应早期发现并干预治疗,延长患者生存时间,提高生活质量。Objective： To understand the clinical and laboratory features of malignant tumor with thrombosis.Methods： Clinical features,blood routine,blood clotting function of 33 in-patients who were diagnosed malignant tumor with thrombosis were retrospectively reviewed.Results： Among these 33 patients,occupied 6.1% of the total,VTE was the most popular one.Thrombosis could be first clinical feature of malignant tumor,44.4% of which had metastasis.The survival time of one year and one year and a half in malignant tumor with thrombosis group was shorter than nonthrombosis.There were significant difference between control and thrombosis group in platelet,white blood cell,PT and D-dimer concentration（P0.05）.Conclusion： Malignant tumor with elevated platelet,white blood cell,DD are prone to complicate thromboembolism event,and with poorly prognosis.It should be detected early and interfered in to improve life.

关 键 词：恶性肿瘤 血栓性疾病 高凝状态 抗凝 

分 类 号：R730.6[医药卫生—肿瘤]