测定季铵盐类药物含量的示波极谱-四苯硼钠滴定法  

Determination of Quaternary Ammonium Drugs by Oscillopolarographic Titration with Sodium Tetraphenylborate

作　　者：孟昭仁[1] 

机构地区：[1]吉林师范学院化学系,吉林132013

出　　处：《分析测试学报》1999年第5期52-59,共8页Journal of Instrumental Analysis

摘　　要：以四苯硼钠 (Na_TPB)为沉淀剂、四乙基氯化铵为滴定剂 ,采用示波极谱滴定法测定氯化琥珀胆碱、溴化新斯的明、碘解磷定3种氢卤酸季铵盐类药物制剂的含量。样品在 pH5.0的NaAc -HAc缓冲溶液中加入过量的四苯硼钠,使试样沉淀完全,过滤后滤液在碱性条件下用四乙基氯化铵标准溶液进行反滴定,由示波极谱图上TPB切口的消失指示滴定终点。该法具有简便、准确、快速的优点,测定结果令人满意。A new method for the determination of succinylcholine chloride, neostigmine bromide and pyraloxime iodide formulations by oscillopolarographic titration with sodium tetraphenylborate(Na _ TPB) has been established. Determined composition in buffer solution of NaAc-HAc(pH 5.0) with excess sodium tetraphenylborate(Na _ TPB) is completely precipitated. After filtration, the filtrate is titrated by tetraethyl ammonium chloride in basic medium of pH 10～12. The end point is indicated by the slot of TPB disappearing sensitively. The method is characterized by simplisity, accuracy and rapidity, and is applied to determine the quaternary ammonium drugs with satisfactory results.

关 键 词：示波极谱 四苯硼钠滴定 季铵盐类 药物含量 测定 

分 类 号：R914.1[医药卫生—药物化学]