微机化的二次微分示波计时电位法测定希夫碱类药物中间体  

Determination of Schiff Bases by Computerized 2nd Order Differentiation Oscillographic Chronopotentiometry

作　　者：于科岐[1] 董社英[1] 李华[1] 高鸿[1] 

机构地区：[1]西北大学分析科学研究所,西安710069

出　　处：《分析化学》1999年第9期1003-1006,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(29775018);陕西省教委基金(98JK114);西北大学科研基金(HF982219)资助课题

摘　　要：提出微机化的二次微分示波计时电位法.在B-R缓冲液(pH 2)中,希夫碱在dE/dt-E示波图上产生灵敏的切口,切口电位E=-0.91V(vs.SCE);在1.80×10^(-5)～1.14×10^(-4)mol/L范围希夫碱的浓度与二次微分曲线上去极剂峰高呈线性关系,r=0.9966;RSD≤6.0%(n=3),合成样品测定回收率在97.0%～102.5%.A method for the determination of schiff bases by using computerized 2nd order differentiation oscillographic chronopotentiometry is developed. In this method, a sensitive incision in oscillogtam in B- R supporting electrolytes (pH 12) is caused by schiff bases and potential of incision is-0.91 V (vs .SCE). The peak height of depolarizer of dE2/dt2 -t curve is proportional to the concentration of schiffbases in the range of 1.80×10-5～1.14×10-4 mol/L. The relative standard deviation (RSD) is lessthan 6% (n=3) . Satisfactory resluts have been achieved in determination of schiff bases in syntheticsamples with a recovery of 97.0%～102.5% .

关 键 词：示波分析 计时电位法 药物分析 席夫碱 中间体 

分 类 号：R914.1[医药卫生—药物化学]