肌营养不良症患者红细胞膜磷脂组成的高效液相色谱分析  

Determination of Phospholipids in Erythrocyte Membrane from Duchenne Muscular Dystrophy by High Performance Liquid Chromatography

作　　者：张抒峰[1] 徐桂云[1] 郭晴[1] 常理文[1] 沈定国[2] 

机构地区：[1]中国科学院化学研究所分子科学中心 [2]解放军总医院,北京100583

出　　处：《分析化学》1999年第9期1058-1060,共3页Chinese Journal of Analytical Chemistry

基　　金：中国科学院化学研究所所长基金资助项目

摘　　要：采用高效液相色谱-紫外检测法对肌营养不良症患者红细胞膜上磷脂的组成进行了分析测定,并将定量结果与正常人的进行了对比,发现肌营养不良症患者红细胞膜中的卵磷脂、脑磷脂、磷脂酰丝氨酸均在正常值范围内,而神经鞘磷脂明显低于正常人的.The phospholipid composition of erythroeyte membrane from 14 patients with duchenne muscular dystrophy (DMD) and 14 normal persons was determined by high performance liquid chromatography. The results indicated that the contents of phosphatidylcholine (P>0.05), phosphatidylethanolamin(P>0.05) and phosphatidylserin (P>0.05) were no significant difference between patients with DMD and normal persons. The interesting observation was the significant variation in the concentration of sphingomyelin (P< 0.05) as compared to normal persons.

关 键 词：肌营养不良症 细胞膜 磷脂 红细胞 HPLC DMD 

分 类 号：R446.112[医药卫生—诊断学]