甲氧基异丁基异腈肿瘤显像对可手术乳腺癌新辅助疗效的预测价值  

Predicative value of ^99mTc-MIBI scintimammography in neoadjuvant chemotherapeutic effect of patients with operable breast cancer

作　　者：刘真真[1] 卢振铎[1] 刘慧[1] 李连方[1] 张恒伟[1] 杨辉[2] 李文亮[2] 崔树德[1] 

机构地区：[1]河南省肿瘤医院乳腺病诊疗中心郑州大学附属肿瘤医院乳腺病诊疗中心,郑州450008 [2]河南省肿瘤医院乳腺病诊疗中心郑州核医学科,郑州450008

出　　处：《中华医学杂志》2011年第6期382-384,共3页National Medical Journal of China

基　　金：河南省科技攻关项目基金（0324410051）

摘　　要：目的观察^99mTc-甲氧基异丁基异腈（^99mTc—MIBI）亲肿瘤显像与乳腺癌新辅助化疗疗效的相关性。方法对78例拟行新辅助化疗的可手术乳腺癌患者进行”^99mTc—MIBI显像，采集10min和180min两时相的平面像，计算放射性清除率。新辅助化疗后进行疗效评价，分析清除率与化疗疗效的相关性。结果新辅助化疗有效64例99mTc—MIBI清除率（14．13±5．98）％；化疗无效14例，^99Tc—MIBI清除率（24．21±6．38）％，两组比较差异有统计学意义。相关分析显示乳腺癌化疗疗效与^99mTc—MIBI在肿瘤中的清除率呈负相关（r=-0．539，P〈0．001）。结论^99mTc．MIBI显像清除率对乳腺癌新辅助化疗疗效具有一定预测价值。Objective To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile （^99mTc-MIBI） in scintimammography and the efficacy of neoadjuvant chemotherapy （NCT） of patients with operable breast cancer. Methods Seventy-eight patients with breast cancer underwent ^99mTc-MIBI scintimammography at pre-NCT. And static planar images were taken at 10 min and 180 rain post-scintimammography. The clearance rate was calculated in each patient. And the efficacy of NCT was evaluated after 2 cycles. Results The clearance rates of patients with a poor or good efficacy of chemotherapy were 24. 21% ±6. 38% （n = 14） and 14. 13% ±5.98% （n =64） respectively. There was significant difference between two groups. And a significant correlation was observed between the efficacy of chemotherapy and the clearance rate of ^99mTc-MIBI （ r = - 0. 539, P 〈 0. 001 ） . Conclusion The scintimammography of ^99mTc-MIBI may be employed to evaluate the efficacy of NCT.

关 键 词：乳腺肿瘤 放射性核素显像 新辅助化疗 甲氧基异丁基异腈 

分 类 号：R737.9[医药卫生—肿瘤]