脑额顶网络损害患者视空间注意功能障碍的研究  

Visuospatial attention deficit in patients with frontoparietal network lesions： Evidence from the attention network test

作　　者：徐光青[1,2] 兰月[3] 陈少贞[2] 裴中[1] 陈玲[1] 黄东锋[2] 

机构地区：[1]中山大学附属第一医院神经内科,广州510080 [2]中山大学附属第一医院康复医学科,广州510080 [3]中山大学附属第三医院康复医学科

出　　处：《中华物理医学与康复杂志》2011年第2期122-125,共4页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家门然科学基金资助项目（81071608）

摘　　要：目的探讨额顶网络损害患者视空间注意网络的解剖和功能定位及其相互影响。方法采用注意网络测试任务，对13例局灶性额叶损害和12例顶叶损害患者进行网络效率测试，并与30例正常对照组的汴意网络测试结果相比较。结果额顶网络损害患者不同提示和刺激类型的平均反应时间均明显比正常对照组慢（P〈0．05）；警觉和定向网络效率及其比率也均明显受损（P〈0．01）。额叶损害患者执行网络效率及其比率与正常对照组比较明显受损（P〈0．01），而顶叶损害患者没有受损，反而网络效率比率还增强（P〈0．01）。结论额顶网络与警觉和定向网络功能有关，而执行控制网络主要与额叶活动有关，并且注意网络测试是研究视觉注意认知过程的有效任务和工具。Objective To probe deficits in visuospatial attention using an attention network test （ANT） in patients with frontoparietal network lesions. Methods The ANT was used to measure the alertness, orienting and executive control abilities of 25 patients with local brain lesions, including 13 with frontal and 12 with parietal damage. Their results were compared with those of health adults. Results During ANT tasks, the patients＇ responses were significantly slower on each cue and target condition than controls＇, and showed deficits in their alerting and orienting networks. The efficiency of executive control was impaired in patients with frontal lesions, but increased with parietal lesions. Conclusions These findings suggest that the frontoparietal network is involved in alerting and orienting, but the executive control function may be selectively associated with the frontal lobe. ANT is an efficient tool for studying visual attention and cognition.

关 键 词：视空间注意 额顶网络 脑损害 注意网络测试 

分 类 号：R741[医药卫生—神经病学与精神病学]