非肿瘤期和肿瘤期蕈样肉芽肿皮损中CXCR3和CD1a的表达  

Expressions of CXCR3 and CD1a in lesions of mycosis fungoides at tumor and non-tumor stages

作　　者：顾琳[1] 晋红中[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《中华皮肤科杂志》2011年第3期158-160,共3页Chinese Journal of Dermatology

摘　　要：目的探讨不同分期蕈样肉芽肿皮损中表皮内CXC趋化因子受体3（CXCR3）和CD1a的表达情况。方法免疫组化法分别检测16例正常人对照、16例非肿瘤期和8例肿瘤期蕈样肉芽肿患者皮损表皮内CXCR3和CD1a的表达情况。结果当蕈样肉芽肿由斑片，斑块期进展至肿瘤期，表皮内淋巴细胞的CXCR3阳性率由38．9％降至17．5％，两者差异有统计学意义。CD1a在正常对照、非肿瘤期蕈样肉芽肿、肿瘤期蕈样肉芽肿表皮内每高倍视野分别含朗格汉斯细胞7．3、10．6、6．7个。非肿瘤期蕈样肉芽肿表皮内朗格汉斯细胞数量明显多于肿瘤期与正常人对照，肿瘤期与正常人对照差异无统计学意义。结论蕈样肉芽肿中亲表皮现象与Th1相关趋化因子受体CXCR3及表皮内朗格汉斯细胞数量有关。Objective To investigate the expressions of CXC chemokine receptor 3 （CXCR3） and CDla in skin lesions of different stages of mycosis fungoides （MF）. Methods The expression and distribution profiles of CDla and CXCR3 were detected by immunohistochemistry in the epidermis of skin samples from 16 normal human controls, 16 patients with non-tumor （patch/plaque） stage MF and 8 patients with tumor stage MF. Results With the progression of MF from patch/plaque stage to tumor stage, the positivity rate of CXCR3 in intraepithelial neoplastic cells in lesions dropped from 38.9% to 17.5% （P 〈 0.05）. The average number of intraepithelial Langerhans cells （LCs） per high power field （HPF） in skin samples was 10.6 in patch/plaque stage MF, significantly higher than that in normal control （7.3） and tumor stage MF （6.7）, while no significant difference was found between normal control and tumor stage MF specimens. Conclusion The epider- motropism in MF may be associated with the expression of T-helper （Th） 1-associated chemokine receptor （CXCR3） and quantity of intraepithelial LCs.

关 键 词：蕈样肉芽肿 淋巴瘤 T细胞 受体 趋化因子 郎格尔汉斯细胞 

分 类 号：R739.5[医药卫生—肿瘤]