延颈髓髓内室管膜瘤预后相关因素分析  

Prognostic analysis of intramedullary ependymomas in medulla oblongata and cervical cord

作　　者：李达[1] 郝淑煜[1] 汤劼[1] 肖新如[1] 吴震[1] 张力伟[1] 张俊廷[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,100050

出　　处：《中华神经外科杂志》2011年第1期11-13,共3页Chinese Journal of Neurosurgery

基　　金：首都医学发展科研基金（2007-2064）

摘　　要：目的 探讨手术治疗的延颈髓髓内室管膜瘤的预后相关因素.方法 对30例手术治疗的延颈髓髓内室管膜瘤病例进行研究并随访,采用KPS评分和改良McCormick分级对手术前后功能进行评价.结果 疼痛为最主要症状,手术可缓解大部分症状;延颈髓髓内室管膜瘤预后与病程显著相关,与年龄、术前KPS评分、肿瘤全切与否、肿瘤长度及放疗等差异无统计学意义;男性预后较差;病理Ⅱ级全切组与近全切加放疗组预后差异无统计学意义.结论 显微外科手术可有效治疗延颈髓髓内室管膜瘤;早期发现、诊断和手术是良好预后的重要因素,未全切者术后行放疗可改善预后.Objective To analyze the factors affecting the operative prognosis of intramedullary ependymomas in medulla oblongata and cervical cord.Method Thirty patients harboring intramedullary ependymomas in medulla oblongata and cervical cord were operated.The preoperative and postoperative status was taken by follow - up and evaluated by Karnofsky Performance Scale （KPS） and Modified McCormick classification system.Results Pain was one of the most common symptoms which could be relieved by operation; there was no statistic significance of age, gender, preoperative status, radical resection and length of the tumor or radiotherapy, while interval was significantly associated with outcomes.The outcome of male was worse than female.There was no significant difference in postoperative status between patients of WHO Ⅱtreated by complete resection and those treated by incomplete resection and radiotherapy.Conclusions Microsurgery is an effective approach for treating intramedullary ependymomas in medulla oblongata and cervical cord.The early detection, diagnosis and radical resection are the key for good prognosis.Postoperative radiotherapy is a beneficial adjuvant treatment.

关 键 词：延髓 室管膜瘤 预后 

分 类 号：R739.4[医药卫生—肿瘤]