无功能型垂体腺瘤患者术前骨密度的改变  

The changes of preoperative bone mineral density of patients with nonfunctional pituitary adenoma

作　　者：赵永博[1] 张小瑞[2] 赵淑娟[3] 干小强[1] 霍军利[1] 章翔[1] 

机构地区：[1]第四军医大学西京医院全军神经外科研究所,西安710032 [2]解放军第三二三医院药剂科 [3]第四军医大学唐都医院传染科

出　　处：《中华神经外科杂志》2011年第2期148-151,共4页Chinese Journal of Neurosurgery

摘　　要：目的 评估无功能型垂体腺瘤患者的骨密度改变,分析影响骨密度改变的相关因素.方法 收集2007年12月至2008年5月间于我科就诊的无功能型垂体腺瘤的患者31例和同期的健康对照组资料255例,对患者组骨密度改变进行评估.并依据患者组术前的激素水平及病程,分析引起无功能型垂体腺瘤患者骨密度改变的相关因素.结果 58%的男性和50%的女性无功能腺瘤患者出现了明显的骨密度减低.无功能腺瘤患者组和对照组骨密度Z值之间差异无统计学意义.Logistic回归分析结果显示：男性患者的骨密度下降和血清睾酮水平下降相关（x2=9.91,P＜0.01,OR=15.75）.结论 无功能型垂体腺瘤患者的骨密度有下降趋势.男性患者血清睾酮水平下降是引起患者骨密度下降的相关因素.Objective To evaluate the bone mineral density （BMD） alteration of patients with nonfunctional pituitary adenoma in Chinese mainland and further to investigate the relevant factors of BMD changement.Methods 31 patients with nonfunctional adenoma and 255 healthy controls were enrolled in this study between December 2007 and May 2008.The Z scores of BMD between the patients and the controls were evaluated.The hormonal activities of the preoperative patients were analyzed to reveal the influencing factors of BMD.Methods The decrease of BMD was identified in 58 percent of male and 50percent of female patients with nonfunctional adenoma.There was no statistical difference in Z score of BMD compared with controls.Logistic Regression analysis indicated that：the decreasing serum test osterone in male patients（x2 =9.91,P ＜0.01 ,OR = 15.75） was the relevant factor of the decreased BMD existed in nonfunctional adenoma patients.Conclusion There was a decreasing trend of BMD in patients with nonfunctional adenoma.The high rate of incidence of hypogonadism in male patients may be the relevant factor of the decreased BMD in patients with nonfunctional adenoma.

关 键 词：无功能型垂体腺瘤 骨质疏松 骨密度 

分 类 号：R736.4[医药卫生—肿瘤]