降纤酶治疗急性脑梗死的效果  

THE CLINICAL CURATIVE EFFECTS OF DEFIBRASE ON PATIENTS WITH ACUTE CEREBRAL INFARCTION

作　　者：徐宝玉[1] 毕崇霞[1] 周云雁[1] 王友芳[1] 迟建丽[1] 王政乾[1] 

机构地区：[1]荣成市人民医院神经内科

出　　处：《齐鲁医学杂志》1999年第2期101-102,共2页Medical Journal of Qilu

摘　　要：①目的探讨降纤酶对急性脑梗死病人的治疗作用。②方法对５０例急性脑梗死病人（治疗组）行降纤酶治疗，分别观察治疗前后血浆凝血因子Ⅰ（Ｆｇ）、凝血因子Ⅱ时间（ＰＴ）、血液流变学及脑电地形图的变化，并与４６例应用维脑路通和７０６代血浆治疗的对照组进行比较。③结果降纤酶治疗后，Ｆｇ明显降低，ＰＴ明显延长，与治疗前比较差异有显著性（ｔ＝３．９２～４．９８，Ｐ＜０．０５，０．０１）。治疗组全血黏度和脑电地形图各波段功率值较治疗前和对照组治疗后明显下降（ｔ＝２．８８～１９．５３，Ｐ＜０．０１）。神经功能缺损和生活能力评分较治疗前明显降低（ｔ＝３．７６～１２．５５，Ｐ＜０．０１）。④结论降纤酶对急性脑梗死具有一定的治疗作用。Objective\ To observe the clinical curative effects of defibrase on patients with acute cerebral infarction(ACI).\ Methods\ The changes of fibrinogen(Fg), prothrombin time (PT), hemorrheology and brainelectronic topographic map(BETM) were observed in 50 ACI patients before and after treatment with defibrase, and compared with that of 46 patients treated with venoruton and 706 plasma.\ Results\ After treatment with defibrase, the Fg was significantly lower and PT was significantly longer than that before treatment( t=3.92-4. 98, P <0.05,0.01), the viscosity and BETM waves were lower than those of patients before treatment and controls after treatment( t =2.88-19.53, P <0.01). The nerve function defect and scores of viability in patients after treatment were lower than those before treatment( t=3.76-12.55,P <0.01).\ Conclusion\ Defibrase might have some treatment effects on ACI patients.

关 键 词：降纤酶 脑梗死 药物疗法 急性 疗效 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]