糖皮质激素治疗对重症肌无力患者BAFF和IL-6水平的影响  

Effects of glucocorticoid therapy on the sera levels of IL-6 and BAFF in patients vnth myasthenia gravis

作　　者：王敏莉[1] 李晓峰[2] 张丽香[2] 秦岭[2] 罗永坚[2] 梅元武[1] 李吕力[2] 

机构地区：[1]华中科技大学附属协和医院神经内科,武汉430022 [2]广西壮族自治区人民医院神经内科,南宁530021

出　　处：《中国临床新医学》2011年第2期107-110,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科自0339028);广西卫生厅中医药科技专项重点项目(编号:GZKZ10-012)

摘　　要：目的探讨糖皮质激素(GC)对新发病重症肌无力(MG)患者外周血B淋巴细胞刺激因子(BAFF)、白介素6(IL-6)水平及临床疗效的影响。方法采用ELISA法检测26例MG患者GC治疗前、后及正常对照组血清BAFF、IL-6水平,并观察GC治疗的临床效果。结果 MG患者外周血清IL-6、BAFF水平明显高于正常对照组水平(P<0.05),激素治疗2个月后,MG患者外周血BAFF、IL-6水平显著下降(t=9.79 ort=3.45,P<0.01),治疗前后IL-6变化与肌无力相对评分存在显著正相关性(r=0.559,P<0.01)。结论 MG患者血清IL-6水平可能与病情严重程度呈正相关,GC可通过抑制IL-6、BAFF分泌,有效调节MG患者细胞免疫功能。Objective To investigate the effect of glueoeortieoid（GC） therapy on the sera levels of interleukin-6（IL-6） and B cell activating factor （BAFF） and the clinical efficacy in new onset patients with myasthenia gravis（MG）. Methods The sera levels of IL-6 and BAFF were measured in 26 patients with MG before and after-treatment and in 30 normal controls （NC） with ELISA. The effeets of GC on patients with MG were assessed by XU Xianhao score system. Results The levels of IL-6 and BAFF of patients with MG were significantly higher than those of NC group（P 〈0.05）. The sera levels of IL-6 and BAFF were drarnatieaUy decreased after 2 months of treatment with GC. There were significant positive correlation between variation of IL-6 concentrations and the relative scores of MG before and after-treatment. Conclusion The level of IL-6 were significantly positively correlated with the severity of MG, GC can effectively regulate the function of cellular immunity by inhibiting the production of IL-6 and BAFF.

关 键 词：重症肌无力 糖皮质激素 白介素6 B淋巴细胞刺激因子 

分 类 号：R746.1[医药卫生—神经病学与精神病学]