活性炭吸附丝裂霉素C腹腔化疗对进展期胃癌术后腹腔复发的影响研究  

Effect of intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles on postoperative peritoneal carcinomatosis of advanced gastric carcinoma

作　　者：田永生[1] 梁寒[2] 

机构地区：[1]天津市天和医院普外科,天津300050 [2]天津市肿瘤医院胃肠肿瘤外科,天津300060

出　　处：《中国中西医结合急救杂志》2011年第2期119-121,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的 观察活性炭吸附丝裂霉素C（MMC-CH）腹腔化疗对进展期胃癌术后腹腔复发的影响.方法 将80例可以行根治手术的进展期胃癌患者按随机原则均分为两组,试验组于手术结束时腹腔内给予MMC-CH（50 mg MMC溶于100 ml生理盐水中,再与375 mg CH混合摇匀,对照组则给予等量的水剂MMC.两组均于术后2个月开始常规静脉化疗并随访,统计两组患者的死亡情况、复发率、平均生存时间及3年、5年生存率.结果 80例患者随访4～62个月,平均34.8个月.试验组死亡12例,复发2例,余26例无瘤生存（49.15±4.56）个月,3年、5年生存率分别为75.62%和48.24%;对照组死亡19例,复发4例,余17例无瘤生存（30.68±2.42）个月,3年、5年生存率分别为35.68%和22.21%.试验组较对照组3年、5年生存率分别提高了39.94%及26.03%（均P〈0.01）.结论 MMC-CH腹腔化疗较水剂MMC腹腔化疗能显著提高进展期胃癌根治性手术后患者生存率.Objective To observe the beneficial effect of intraperitoneally applied mitomycin C bound to activated carbon particles （MMC-CH） on preventing and treating intra-abdominaI recurrence following curative surgery for advanced gastric carcinoma. Methods A total of 80 patients with a radically reseeted gastric cancer infiltrating the serosal surface were randomly divided into treatment group （40 cases） and control group （40 cases）. The treatment group received 50 mg mitomycin C bound to a solution of 375 mg carbon adsorbent intraperitoneally before the closure of the abdominal wound, while the control group received 50 mg mitomycin C in 100 ml physiological saline intraperitoneally before the closure of the abdominal wound. Two months after surgery, the systemic conventional chemotherapy began to administer in both groups, and the following-up was conducted. The fatality rate, relapse rate, the average survival time, 3-year and 5-year survival rates were recorded in both groups. Results The average period of following-up was 34.8 months （4 62 months）. During the follow-up, in the treatment group, 12 cases were dead, the disease recurred in 2 patients, and the average disease-free survival time of 26 cases was （49.15±4.56） months. The recurrence- free of 3-year and 5-year survival rates were 75.62% and 48.24%, respectively; in the eontrol group, 19 cases were dead, the disease recurred in 4 patients, and the average disease-free survival time of 17 cases was （30.68±2.42） months. The recurrence-free of 3-year and 5-year survival rates were 35.68% and 22.21%, respectively. Compared with the control group, the recurrence-free of 3-year and 5-year survival rates were improved by 39.94% and 26.03%, respectively in the treatment group （both P〈0.01）. Conclusion Adjuvant intra-peritoneal chemotherapy with mitomycin C bound to activated carbon particles compared to that with mitomycin C dissolved in normal saline, the former one can significantly increase the postoperative survival rate in cases

关 键 词：胃癌 腹腔化疗 活性炭 丝裂霉素C 

分 类 号：R735.2[医药卫生—肿瘤] R453[医药卫生—临床医学]