双歧杆菌活菌胶囊预防CPT-11引起的化疗相关性腹泻的疗效观察  

A clinical trial on preventive efficacy on CPT-11-induced diarrhea by bifidobacterium capsules

作　　者：方立萍[1] 吴紫权 宋晨[1] 郑培实[1] 陈骏[1] 

机构地区：[1]大连医科大学附属第二医院肿瘤内科,辽宁大连116023 [2]大连沙医生整形美容口腔专科医院,辽宁大连116023

出　　处：《中国微生态学杂志》2011年第3期241-242,共2页Chinese Journal of Microecology

摘　　要：目的观察双歧杆菌活菌胶囊预防伊立替康(CPT-11)引起的化疗相关性腹泻的疗效。方法 36例患者随机分成2组,观察组:化疗+双歧杆菌活菌胶囊,对照组:单纯化疗。观察患者治疗前后的KPS评分和腹泻的发生率及分级。结果观察组化疗前后KPS评分无明显变化,对照组化疗后KPS评分明显下降,差异有统计学意义,观察组Ⅰ～Ⅱ级腹泻发生率为33.3%,对照组为50%,2组差异有统计学意义(P<0.01)。观察组Ⅲ～Ⅳ级腹泻发生率为5.5%,对照组为27.8%,2组差异有统计学意义(P<0.01)。结论应用双歧杆菌活菌胶囊预防化疗相关性腹泻有良好的效果。Objective To observe the preventive efficacy on CPT-11-induced diarrhea by bifidobacterium capsules. Method 36 patients were randomized into observation group treated with chemotherapy plus bifidobacterium capsules and control with chemotherapy alone.Karnofsky performance status（KPS）,diarrhea incidence and its grade were recorded for each patient both at baseline and post treatment. Result Compared with the baseline,KPS post chemotherapy showed no statistical difference in the observation group,but a significant drop in the control.Incidences of 33.3% and 5.5% were observed respectively for diarrhea in gradeⅠ~Ⅱ and in grade III^IV,compared with 50% and 27.8% respectively in the control,both with significant difference（P〈0.01 and P〈0.01）. Conclusion Bifidobacterium capsules may be considered as an effective approach to prevent chemotherapy-induced diarrhea.

关 键 词：化疗 腹泻 双歧杆菌 CPT-11 

分 类 号：R378.992[医药卫生—病原生物学]